Evidence map›Paper›PMID 35443895›Full record

ArticleInternational journal of neural systems2022

Quantitative Assessment of Electroencephalogram Reactivity in Comatose Patients on Extracorporeal Membrane Oxygenation.

Autumn Williams, Yinuo Zeng, Ziwei Li, Nitish Thakor, Romergryko G Geocadin, Jay Bronder, Nirma Carballido Martinez, Eva K Ritzl, Sung-Min Cho

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of neural systems, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Autumn WilliamsDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Yinuo ZengDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Ziwei LiDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Nitish ThakorDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Romergryko G GeocadinDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jay BronderDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Nirma Carballido MartinezDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Eva K RitzlDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sung-Min ChoDepartment of Neurology, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Phipps 455, Baltimore, MD, USA.
Johns Hopkins University · USJohns Hopkins Medicine · US

Funding

Consequences of Cardiac Arrest: Brain InjuryR01HL071568 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI GEOCADIN, ROMERGRYKO, THAKOR, NITISH VYOMESH · 2003 to 2022
$8.4M
CLots and Oxygen in Va-ExtracorpoReal membrane oxygenation (CLOVER) studyK23HL157610 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Sung-Min Cho · 2022 to 2026
$797k
NHLBI NIH HHS K23 HL157610NHLBI NIH HHS R01 HL071568
6 · The paper itself

Abstract

Objective assessment of the brain's responsiveness in comatose patients on Extracorporeal Membrane Oxygenation (ECMO) support is essential to clinical care, but current approaches are limited by subjective methodology and inter-rater disagreement. Quantitative electroencephalogram (EEG) algorithms could potentially assist clinicians, improving diagnostic accuracy. We developed a quantitative, stimulus-based algorithm to assess EEG reactivity features in comatose patients on ECMO support. Patients underwent a stimulation protocol of increasing intensity (auditory, peripheral, and nostril stimulation). A total of 129 20-s EEG epochs were collected from 24 patients (age [Formula: see text], 10 females, 14 males) on ECMO support with a Glasgow Coma Scale[Formula: see text]8. EEG reactivity scores ([Formula: see text]-scores) were calculated using aggregated spectral power and permutation entropy for each of five frequency bands ([Formula: see text], [Formula: see text], [Formula: see text], [Formula: see text], [Formula: see text]. Parameter estimation techniques were applied to [Formula: see text]-scores to identify properties that replicate the decision process of experienced clinicians performing visual analysis. Spectral power changes from audio stimulation were concentrated in the [Formula: see text] band, whereas peripheral stimulation elicited an increase in spectral power across multiple bands, and nostril stimulation changed the entropy of the [Formula: see text] band. The findings of this pilot study on [Formula: see text]-score lay a foundation for a future prediction tool with clinical applications.

Indexed as

ComaExtracorporeal Membrane OxygenationElectroencephalographyEntropyFemaleHumansMalePilot Projectscomadisorder of consciousnessECMOEEG reactivityQuantitative EEGregression analysis

Identifiers

PMID35443895
PMCPMC9436243
OpenAlexW4224276507

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.