Evidence map›Paper›PMID 35443830›Full record

Trial reportJournal of psychopharmacology (Oxford, England)2022

Catechol-O-methyltransferase activity does not influence emotional processing in men.

Marieke Ag Martens, Nina Dalton, Jessica Scaife, Catherine J Harmer, Paul J Harrison, Elizabeth M Tunbridge

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of psychopharmacology (Oxford, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Marieke Ag MartensDepartment of Psychiatry, University of Oxford, Oxford, UK.ORCID 0000-0003-0108-1327
Nina DaltonDepartment of Psychiatry, University of Oxford, Oxford, UK.
Jessica ScaifeDepartment of Psychiatry, University of Oxford, Oxford, UK.
Catherine J HarmerDepartment of Psychiatry, University of Oxford, Oxford, UK.
Paul J HarrisonDepartment of Psychiatry, University of Oxford, Oxford, UK.ORCID 0000-0002-6719-1126
Elizabeth M TunbridgeDepartment of Psychiatry, University of Oxford, Oxford, UK.ORCID 0000-0002-2966-2281
Oxford Health NHS Foundation Trust · GBUniversity of Oxford · GB

Funding

Medical Research Council MR/K013092/1
6 · The paper itself

Abstract

backgroundCatechol-O-methyltransferase (COMT) regulates cortical dopaminergic transmission and prefrontal-dependent cognitive function. However, its role in other cognitive processes, including emotional processing, is relatively unexplored. We therefore investigated the separate and interactive influences of COMT inhibition and Val

methodsWe recruited 74 healthy men homozygous for the functional COMT Val

resultsThere were no main or interactive effects of Val

conclusionsOur findings suggest that, at least in healthy adult men, COMT has little or no effect on emotional processing or mood. These findings contrast with several neuroimaging studies that suggest that COMT modulates neural activity during emotional processing. Thus, further studies are required to understand how COMT impacts on the relationship between behavioural output and neural activity during emotional processing. Nevertheless, our data suggest that novel COMT inhibitors under development for treating cognitive dysfunction are unlikely to have acute off target effects on emotional behaviours.

Indexed as

Catechol O-MethyltransferaseCatechol O-Methyltransferase InhibitorsAdultBrainCognitionDouble-Blind MethodGenotypeHumansMaleTolcaponeCatechol O-MethyltransferaseCatechol O-Methyltransferase InhibitorsTolcaponeantidepressantcognitionDopamineemotional processingmoodtolcapone

Identifiers

PMID35443830
PMCPMC9150146
OpenAlexW4224248786

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.