Evidence map›Paper›PMID 35443566›Full record

ArticleHaematologica2022

A novel BCMA CAR-T-cell therapy with optimized human scFv for treatment of relapsed/refractory multiple myeloma: results from phase I clinical trials.

Min Yang, Wenhao Zhang, Kang Yu, Peng Wang, Hua Jiang, Linjun Chen, Haitao Meng, Yiqin Weng, Rong Tao, Xin Huang and 13 more

Open access · goldAbstract read
In one paragraph

Article in Haematologica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  14. Zevorcabtagene Autoleucel: First Approval.Molecular diagnosis & therapy · 2024
    Review
  15. Molecular and therapeutic effect of CRISPR in treating cancer.Medical oncology (Northwood, London, England) · 2023
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 5 institutions in 1 country.

Min Yang *Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou. jiej0503@163.com.
Wenhao Zhang *Department of Hematology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai. haosiguo@xinhuamed.com.cn
Kang Yu *Department of Hematology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou. jiej0503@163.com.
Peng Wang *State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Hua Jiang *CARsgen Therapeutics Co. Ltd, Shanghai.
Linjun Chen *Department of Hematology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai. haosiguo@xinhuamed.com.cn
Haitao Meng *Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou. jiej0503@163.com.
Yiqin Weng *Department of Hematology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou. jiej0503@163.com.
Rong Tao *Department of Hematology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai. haosiguo@xinhuamed.com.cn
Xin Huang *Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou. jiej0503@163.com.
Chongyun Xing *Department of Hematology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou. jiej0503@163.com.
Huamao Wang *CARsgen Therapeutics Co. Ltd, Shanghai.
Jiangbo Wan *Department of Hematology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai. haosiguo@xinhuamed.com.cn
Shasha Wang *Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou. jiej0503@163.com.
Lihui Dai *Department of Hematology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou. jiej0503@163.com.
Amanda Y Hendrix *CARsgen Therapeutics Corp., Houston, TX.
Jun Xiao *CARsgen Therapeutics Co. Ltd, Shanghai.
Wei Wang *CARsgen Therapeutics Co. Ltd, Shanghai.
Hong Ma *CARsgen Therapeutics Corp., Houston, TX.
Siguo Hao *State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zonghaili@shsmu.edu.cn.
Jie Jin *Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou. jiej0503@163.com.
Zonghai Li *CARsgen Therapeutics Co. Ltd, Shanghai.
Songfu Jiang *Department of Hematology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou. jiej0503@163.com.
First Affiliated Hospital of Wenzhou Medical University · CNFirst Affiliated Hospital Zhejiang University · CNShanghai Jiao Tong University · CNXinHua Hospital · CNState Key Laboratory of Oncogene and Related Genes · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Multiple MyelomaNeoplasms, Plasma CellReceptors, Chimeric AntigenB-Cell Maturation AntigenCell- and Tissue-Based TherapyClinical Trials, Phase I as TopicHumansImmunotherapy, AdoptiveB-Cell Maturation AntigenReceptors, Chimeric Antigen

Identifiers

PMID35443566
PMCPMC9335117
OpenAlexW4224241187

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.