Evidence map›Paper›PMID 35443165›Full record

ArticleCell reports2022

Escargot controls somatic stem cell maintenance through the attenuation of the insulin receptor pathway in Drosophila.

Rafael Sênos Demarco, Brian J Stack, Alexander M Tang, Justin Voog, Sharsti L Sandall, Tony D Southall, Andrea H Brand, D Leanne Jones

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Rafael Sênos DemarcoDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Brian J StackDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Alexander M TangDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Justin VoogLaboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Sharsti L SandallLaboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Tony D SouthallDepartment of Life Sciences, Imperial College London, Sir Ernst Chain Building, London SW7 2AZ, UK.
Andrea H BrandThe Gurdon Institute and Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 1QN, UK.
D Leanne JonesDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Anatomy, Division of Geriatrics, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Medicine, Division of Geriatrics, University of California, San Francisco, San Francisco, CA 94143, USA; Eli and Edythe Broad Center for Regeneration Medicine, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: leanne.jones@ucsf.edu.
University of California, Los Angeles · USSalk Institute for Biological Studies · USImperial College London · GBUniversity of California, San Francisco · USUniversity of Cambridge · GB

Funding

Metabolic regulation of stem cell behavior and longevityR01AG040288 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JONES, DANA LEANNE, WALKER, DAVID W · 2012 to 2016
$3.0M
Lipid mediated regulation of stem cell behavior and tissue homeostasisR01GM135767 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JONES, DANA LEANNE · 2020 to 2023
$1.8M
Regulation of intestinal stem cell behavior by occluding junctionsR01DK105442 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JONES, DANA LEANNE · 2017 to 2020
$1.7M
New tools for investigating mitochondrial dynamics in stem cells during agingR21AG052732 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JONES, DANA LEANNE · 2016 to 2017
$424k
Cancer Research UK A14492Cancer Research UK C6946NIA NIH HHS R01 AG040288NIA NIH HHS R21 AG052732NIDDK NIH HHS R01 DK105442NIGMS NIH HHS R01 GM135767Wellcome Trust 092096Wellcome Trust 092545Wellcome Trust 103792Wellcome Trust 104567
6 · The paper itself

Abstract

Adult stem cells coordinate intrinsic and extrinsic, local and systemic, cues to maintain the proper balance between self-renewal and differentiation. However, the precise mechanisms stem cells use to integrate these signals remain elusive. Here, we show that Escargot (Esg), a member of the Snail family of transcription factors, regulates the maintenance of somatic cyst stem cells (CySCs) in the Drosophila testis by attenuating the activity of the pro-differentiation insulin receptor (InR) pathway. Esg positively regulates the expression of an antagonist of insulin signaling, ImpL2, while also attenuating the expression of InR. Furthermore, Esg-mediated repression of the InR pathway is required to suppress CySC loss in response to starvation. Given the conservation of Snail-family transcription factors, characterizing the mechanisms by which Esg regulates cell-fate decisions during homeostasis and a decline in nutrient availability is likely to provide insight into the metabolic regulation of stem cell behavior in other tissues and organisms.

Indexed as

Adult Stem CellsDrosophila ProteinsAnimalsCell DifferentiationDrosophilaDrosophila melanogasterInsulin-Like Growth Factor Binding ProteinsMaleReceptor, InsulinTestisTranscription FactorsDrosophila ProteinsImpL2 protein, DrosophilaInsulin-Like Growth Factor Binding ProteinsReceptor, InsulinTranscription FactorsCP: Developmental biologyCP: Stem cell researchcyst stem cellsDrosophilaescargotImpL2InRinsulinmetabolismtestis

Identifiers

PMID35443165
PMCPMC9043617
OpenAlexW4224293041

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.