Evidence map›Paper›PMID 35443003›Full record

ArticlePloS one2022

Infectious diseases, comorbidities and outcomes in hospitalized people who inject drugs (PWID)

Jacqueline Lim, Sureka Pavalagantharajah, Chris P Verschoor, Eric Lentz, Mark Loeb, Mitchell Levine, Marek Smieja, Lawrence Mbuagbaw, Dale Kalina, Jean-Eric Tarride and 8 more

Erratum issuedAbstract read
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Jacqueline LimFaculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Sureka PavalagantharajahDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Chris P VerschoorHealth Sciences North Research Institute, Sudbury, Ontario, Canada.
Eric LentzDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Mark LoebPathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Mitchell LevineDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.
Marek SmiejaPathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Lawrence MbuagbawDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.
Dale KalinaDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Jean-Eric TarrideDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.
Tim O'SheaDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Anna CvetkovicDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Sarah van GaalenDepartment of Family Medicine, Queen's University, Kingston, Ontario, Canada.
Aidan Reid FindlaterDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0003-4698-7536
Robin LennoxDepartment of Family Medicine, McMaster University, Hamilton, Ontario, Canada.
Carol BassimDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Cynthia LokkerDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.
Elizabeth AlvarezDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0003-2333-0144

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Injection drug use poses a public health challenge. Clinical experience indicates that people who inject drugs (PWID) are hospitalized frequently for infectious diseases, but little is known about outcomes when admitted. Charts were identified from local hospitals between 2013-2018 using consultation lists and hospital record searches. Included individuals injected drugs in the past six months and presented with infection. Charts were accessed using the hospital information system, undergoing primary and secondary reviews using Research Electronic Data Capture (REDCap). The Wilcoxon rank-sum test was used for comparisons between outcome categories. Categorical data were summarized as count and frequency, and compared using Fisher's exact test. Of 240 individuals, 33% were admitted to the intensive care unit, 36% underwent surgery, 12% left against medical advice (AMA), and 9% died. Infectious diagnoses included bacteremia (31%), abscess (29%), endocarditis (29%), cellulitis (20%), sepsis (10%), osteomyelitis (9%), septic arthritis (8%), pneumonia (7%), discitis (2%), meningitis/encephalitis (2%), or other (7%). Sixty-six percent had stable housing and 60% had a family physician. Fifty-four percent of patient-initiated discharges were seen in the emergency department within 30 days and 29% were readmitted. PWID are at risk for infections. Understanding their healthcare trajectory is essential to improve their care.

Indexed as

Communicable DiseasesDrug UsersEndocarditisSubstance Abuse, IntravenousHospitalizationHumans

Identifiers

PMID35443003
PMCPMC9020696

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.