Evidence map›Paper›PMID 35442873›Full record

ArticleOcular immunology and inflammation2022

Grading Anterior Chamber Inflammation with Anterior Segment Optical Coherence Tomography: An Overview.

Morgan Maring, Steven S Saraf, Marian Blazes, Sumit Sharma, Sunil Srivastava, Kathryn L Pepple, Cecilia S Lee

Abstract read
In one paragraph

Article in Ocular immunology and inflammation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Monitoring Behçet uveitis.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Morgan MaringKeck School of Medicine of University of Southern California, University of Southern California, Los Angeles, California, USA.
Steven S SarafDepartment of Ophthalmology, University of Washington, Seattle, Washington, USA.
Marian BlazesDepartment of Ophthalmology, University of Washington, Seattle, Washington, USA.
Sumit SharmaCole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Sunil SrivastavaCole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Kathryn L PeppleDepartment of Ophthalmology, University of Washington, Seattle, Washington, USA.
Cecilia S LeeDepartment of Ophthalmology, University of Washington, Seattle, Washington, USA.

Funding

Translational pharmacoepidemiology: neuroprotection and neurotoxicity of antihypertensives and strong anticholinergicsU19AG066567 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI Paul K Crane, Andrea Z. LaCroix · 2021 to 2026
$80.4M
Aging eyes and aging brains in studying alzheimer's disease: Modern ophthalmic data collection in the adult changes in thought (ACT) studyR01AG060942 · NIA · WASHINGTON UNIVERSITY · PI Cecilia Sungmin Lee · 2019 to 2026
$39.4M
NIA NIH HHS R01 AG060942NIA NIH HHS U19 AG066567
6 · The paper itself

Abstract

The objective grading of anterior chamber inflammation (ACI) has remained a challenge in the field of uveitis. While the grading criteria produced by the Standardization of Uveitis Nomenclature (SUN) International Workshop have been widely adopted, limitations exist including interobserver variability and grading confined to discrete categories rather than a continuous measurement. Since the earliest iterations of optical coherence tomography (OCT), ACI has been assessed using anterior segment OCT and shown to correlate with slit-lamp findings. However, widespread use of this approach has not been adopted. Barriers to standardization include variability in OCT devices across clinical settings, lack of standardization of image acquisition protocols, varying quantification methods, and the difficulty of distinguishing inflammatory cells from other cell types. Modern OCT devices and techniques in artificial intelligence show promise in expanding the clinical applicability of anterior segment OCT for the grading of ACI.

Indexed as

UveitisUveitis, AnteriorAnterior ChamberArtificial IntelligenceHumansInflammationTomography, Optical CoherenceAnterior uveitisartificial intelligenceclinical gradingoptical coherence tomographyreview

Identifiers

PMID35442873
PMCPMC9038027

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.