Evidence map›Paper›PMID 35442828›Full record

ArticleAmerican journal of physiology. Cell physiology2022

Estradiol deficiency reduces the satellite cell pool by impairing cell cycle progression.

Alexie A Larson, Ahmed S Shams, Shawna L McMillin, Brian P Sullivan, Cha Vue, Zachery A Roloff, Eric Batchelor, Michael Kyba, Dawn A Lowe

Open access · hybridAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Elevated mitochondrial CaStem cell reports · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Sexual dimorphisms in skeletal muscle: current concepts and research horizons.Journal of applied physiology (Bethesda, Md. : 1985) · 2024
    Review
  11. Ablation of skeletal muscle estrogen receptor alpha impairs contractility in male mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2024
    Article
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Alexie A LarsonDepartment of Integrative Biology and Physiology, Medical School, University of Minnesota, Minneapolis, Minnesota.ORCID 0000-0003-0807-1172
Ahmed S ShamsLillehei Heart Institute, Medical School, University of Minnesota, Minneapolis, Minnesota.
Shawna L McMillinDivisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota.ORCID 0000-0002-2229-8747
Brian P SullivanDivisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota.
Cha VueDivisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota.
Zachery A RoloffDivisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota.
Eric BatchelorDepartment of Integrative Biology and Physiology, Medical School, University of Minnesota, Minneapolis, Minnesota.
Michael KybaLillehei Heart Institute, Medical School, University of Minnesota, Minneapolis, Minnesota.
Dawn A LoweDivisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota.
University of Minnesota Medical Center · USSuez Canal University · EGUniversity of Minnesota · US

Funding

TRAINING PROGRAM IN MUSCLE RESEARCHT32AR007612 · NIAMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI JAMES M ERVASTI, DAWN A LOWE · 2001 to 2026
$11.3M
Interatction of Estrogen, Age and Activity on Musculoskeletal Strength in FemalesR01AG031743 · NIA · UNIVERSITY OF MINNESOTA · PI DAWN A LOWE · 2009 to 2026
$7.4M
Training Grant: Functional Proteomics of AgingT32AG029796 · NIA · UNIVERSITY OF MINNESOTA · PI EDGAR A ARRIAGA, Douglas G Mashek · 2008 to 2026
$6.6M
Dissecting Effects of Estrogen Deficiency on Satellite Cells and Muscle Regeneration in Females and MalesR01AG062899 · NIA · UNIVERSITY OF MINNESOTA · PI KYBA, MICHAEL, LOWE, DAWN A · 2019 to 2023
$2.5M
NIAMS NIH HHS T32 AR007612NIA NIH HHS R01 AG031743NIA NIH HHS R01 AG062899NIA NIH HHS T32 AG029796
6 · The paper itself

Abstract

The size of the satellite cell pool is reduced in estradiol (E

Indexed as

EstradiolMuscle, SkeletalAnimalsCell DivisionFemaleHumansMiceMyoblastsOvariectomyEstradiolmuscle stem cellsovariectomysatellite cell cyclingskeletal muscle

Identifiers

PMID35442828
PMCPMC9169829
OpenAlexW4224253050

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.