Evidence map›Paper›PMID 35442745›Full record

ArticleScience advances2022

Mechanism of stress-induced attacks in an episodic neurologic disorder.

Heather D Snell, Ariel Vitenzon, Esra Tara, Chris Chen, Jaafar Tindi, Bryen A Jordan, Kamran Khodakhah

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
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  3. Cerebellar α1Cellular and molecular life sciences : CMLS · 2025
    Article
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  7. More Than a Small Brain: The Importance of Studying Neural Function during Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Episodic ataxia type 2 (EA2) with interictal myokymia and focal dystonia.Cold Spring Harbor molecular case studies · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Heather D SnellDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA.ORCID 0000-0001-9377-3579
Ariel VitenzonDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Esra TaraDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Chris ChenDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA.ORCID 0000-0002-4611-8667
Jaafar TindiDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA.ORCID 0000-0001-9293-2451
Bryen A JordanDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Kamran KhodakhahDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA.ORCID 0000-0001-7905-5335
Albert Einstein College of Medicine · US

Funding

The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve HealthUL1TR002733 · NCATS · OHIO STATE UNIVERSITY · PI RINGEL, MATTHEW D · 2018 to 2022
$28.9M
SUPPORT FOR THE ROSE F KENNEDY IDDRC P50P50HD105352 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SOPHIE MOLHOLM, Steven Upshaw Walkley · 2021 to 2026
$7.0M
LIFE CYCLE EVENTS, PRODUCTIVITY, AND SCIENTIFIC IMPACTP01AG039347 · NIA · NATIONAL BUREAU OF ECONOMIC RESEARCH · PI WEINBERG, BRUCE A · 2013 to 2018
$5.4M
Cerebellar Function in Health and DiseaseR01NS050808 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KHODAKHAH, KAMRAN · 2006 to 2016
$3.9M
ANKS1B haploinsufficiency in a novel brain disorderR01NS118820 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI JORDAN, BRYEN ALEXANDER · 2020 to 2024
$2.2M
Invisible Collaborators: Underrepresentation, Research Networks, and Outcomes of Biomedical Researchers R01GM140281 · NIGMS · OHIO STATE UNIVERSITY · PI OWEN-SMITH, JASON DAVID, WEINBERG, BRUCE A · 2020 to 2023
$869k
AIDA-1 in NMDA receptor function and anxietyR56MH115201 · NIMH · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JORDAN, BRYEN ALEXANDER · 2018 to 2019
$835k
NCATS NIH HHS UL1 TR002733NIA NIH HHS P01 AG039347NICHD NIH HHS P50 HD105352NIGMS NIH HHS R01 GM140281NIMH NIH HHS R56 MH115201NINDS NIH HHS R01 NS050808NINDS NIH HHS R01 NS118820
6 · The paper itself

Abstract

Stress is the most common trigger among episodic neurologic disorders. In episodic ataxia type 2 (EA2), physical or emotional stress causes episodes of severe motor dysfunction that manifest as ataxia and dystonia. We used the

Identifiers

PMID35442745
PMCPMC9020779
OpenAlexW4224211097

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.