ArticleScience advances2022
A unified model of the task-evoked pupil response.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Altered Theory of Mind Engagement and Neural Alignment in Social Anxiety During Movie Viewing.Biological psychiatry global open science · 2026Article
- Interactions across hemispheres in prefrontal cortex reflect global cognitive processing.Nature communications · 2026Article
- Microsaccadic modulation in goal-directed reaching.Journal of vision · 2026Article
- Article
- Dissociable Pupil and Oculomotor Markers of Attention Allocation and Distractor Suppression during Listening.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Oculomotor chronometry of spoken word structure processing.Scientific reports · 2025Article
- Spontaneous movements and their relationship to neural activity fluctuate with latent engagement states.Neuron · 2025Article
- Locus coeruleus tonic upregulation increases selectivity to inconspicuous auditory information in autistic compared to non-autistic individuals: a combined pupillometry and electroencephalography study.Molecular autism · 2025Article
- Eyes on hold: motion task difficulty jointly delays microsaccade and pupil responses.Scientific reports · 2025Article
- Interactions across hemispheres in prefrontal cortex reflect global cognitive processing.bioRxiv : the preprint server for biology · 2025Article
- Article
- Neurovascular coupling: a review of spontaneous neocortical dynamics linking neuronal activity to hemodynamics and what we have learned from the rodent brain.Journal of neurophysiology · 2025Review
- Brain responses vary in duration-modeling strategies and challenges.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Saccades track visual associative memory processes with precision and sensitivity.Brain communications · 2025Article
- Fixational saccade inhibition and pupil dilation during self-paced limb movement preparation.PloS one · 2025Article
- VARX Granger analysis: Models for neuroscience, physiology, sociology and econometrics.PloS one · 2025Article
- Pupil-linked arousal, cortical activity, and cognition in Alzheimer's disease.Brain communications · 2025Article
- Pupillary responses to directional uncertainty while intercepting a moving target.Royal Society open science · 2024Article
- Individual differences in belief updating and phasic arousal are related to psychosis proneness.Communications psychology · 2024Article
- Touchless short-wave infrared imaging for dynamic rapid pupillometry and gaze estimation in closed eyes.Communications medicine · 2024Article
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Authors and funding
3 authors.
Funding
Abstract
The pupil dilates and reconstricts following task events. It is popular to model this task-evoked pupil response as a linear transformation of event-locked impulses, whose amplitudes are used as estimates of arousal. We show that this model is incorrect and propose an alternative model based on the physiological finding that a common neural input drives saccades and pupil size. The estimates of arousal from our model agreed with key predictions: Arousal scaled with task difficulty and behavioral performance but was invariant to small differences in trial duration. Moreover, the model offers a unified explanation for a wide range of phenomena: entrainment of pupil size and saccades to task timing, modulation of pupil response amplitude and noise with task difficulty, reaction time-dependent modulation of pupil response timing and amplitude, a constrictory pupil response time-locked to saccades, and task-dependent distortion of this saccade-locked pupil response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.