Evidence map›Paper›PMID 35442729›Full record

ArticleScience advances2022

Portable, low-field magnetic resonance imaging enables highly accessible and dynamic bedside evaluation of ischemic stroke.

Matthew M Yuen, Anjali M Prabhat, Mercy H Mazurek, Isha R Chavva, Anna Crawford, Bradley A Cahn, Rachel Beekman, Jennifer A Kim, Kevin T Gobeske, Nils H Petersen and 17 more

Abstract read
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed.

  1. Trial
  2. Article
  3. MultidimensionalbioRxiv : the preprint server for biology · 2026
    Article
  4. Review
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  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Ultra-low fieldCommunications chemistry · 2026
    Article
  17. Article
  18. Review
  19. Article
  20. On the accuracy of image registration in portable low-field 3D brain MRI.bioRxiv : the preprint server for biology · 2026
    Article

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Matthew M YuenDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-2431-8534
Anjali M PrabhatDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.
Mercy H MazurekDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.
Isha R ChavvaDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.
Anna CrawfordDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.
Bradley A CahnDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-1553-4446
Rachel BeekmanDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.
Jennifer A KimDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-3072-6198
Kevin T GobeskeDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.
Nils H PetersenDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-9711-3340
Guido J FalconeDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-6407-0302
Emily J GilmoreDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.
David Y HwangDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.
Adam S JasneDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-9092-3607
Hardik AminDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.
Richa SharmaDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-0798-2353
Charles MatoukDepartment of Neurosurgery, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-3234-9541
Adrienne WardNeuroscience Intensive Care Unit, Yale New Haven Hospital, New Haven, CT, USA.ORCID 0000-0002-2306-5013
Joseph SchindlerDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.
Lauren SansingDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-6898-1680
Adam de HavenonDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-8178-8597
Ani AydinDepartment of Emergency Medicine, Yale School of Medicine, New Haven, CT, USA.
Charles WiraDepartment of Emergency Medicine, Yale School of Medicine, New Haven, CT, USA.
Gordon SzeDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Matthew S RosenAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.ORCID 0000-0002-7194-002X
W Taylor KimberlyDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-2519-8530
Kevin N ShethDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-2003-5473

Funding

Anticoagulation in ICH Survivors for Prevention and Recovery (ASPIRE)U01NS106513 · NINDS · YALE UNIVERSITY · PI Hooman Kamel, Kevin Navin Sheth · 2019 to 2026
$20.6M
Portable, Low Field Brain Magnetic Resonance Imaging (MRI) for Acute StrokeR01EB031114 · NIBIB · YALE UNIVERSITY · PI William Taylor Kimberly, Matthew Scot Rosen · 2022 to 2026
$3.5M
The Recovery in Stroke Using PAP (RISE UP) StudyR01NR018335 · NINR · YALE UNIVERSITY · PI REDEKER, NANCY S, SHETH, KEVIN NAVIN · 2019 to 2023
$3.4M
Southern New England Partnership In Stroke Research, Innovation and Treatment (SPIRIT)U24NS107215 · NINDS · YALE UNIVERSITY · PI MARK Jay ALBERTS, Karen L Furie · 2018 to 2026
$3.0M
Improved glyburide therapy via acid- triggered release functional nanoparticles and therapeutic imagingR01NS110721 · NINDS · YALE UNIVERSITY · PI SHETH, KEVIN NAVIN, ZHOU, JIANGBING · 2019 to 2023
$1.9M
Yale Clinical Site: Investigations For Improved Neurological Treatments at Yale (INFINITY)U24NS107136 · NINDS · YALE UNIVERSITY · PI SHETH, KEVIN NAVIN, SPUDICH, SERENA S · 2018 to 2022
$1.7M
Precision blood pressure management after endovascular stroke therapy based on real-time autoregulation measurementsK23NS110980 · NINDS · YALE UNIVERSITY · PI PETERSEN, NILS H. · 2020 to 2024
$951k
Intensive Blood Pressure Reduction in Deep Intracerebral HemorrhageR03NS112859 · NINDS · YALE UNIVERSITY · PI FALCONE, GUIDO JOSE, SHETH, KEVIN NAVIN · 2019 to 2020
$84k
NIBIB NIH HHS R01 EB031114NINDS NIH HHS K23 NS110980NINDS NIH HHS R01 NS110721NINDS NIH HHS R03 NS112859NINDS NIH HHS U01 NS106513NINDS NIH HHS U24 NS107136NINDS NIH HHS U24 NS107215NINR NIH HHS R01 NR018335
6 · The paper itself

Abstract

Brain imaging is essential to the clinical management of patients with ischemic stroke. Timely and accessible neuroimaging, however, can be limited in clinical stroke pathways. Here, portable magnetic resonance imaging (pMRI) acquired at very low magnetic field strength (0.064 T) is used to obtain actionable bedside neuroimaging for 50 confirmed patients with ischemic stroke. Low-field pMRI detected infarcts in 45 (90%) patients across cortical, subcortical, and cerebellar structures. Lesions as small as 4 mm were captured. Infarcts appeared as hyperintense regions on T2-weighted, fluid-attenuated inversion recovery and diffusion-weighted imaging sequences. Stroke volume measurements were consistent across pMRI sequences and between low-field pMRI and conventional high-field MRI studies. Low-field pMRI stroke volumes significantly correlated with stroke severity and functional outcome at discharge. These results validate the use of low-field pMRI to obtain clinically useful imaging of stroke, setting the stage for use in resource-limited environments.

Identifiers

PMID35442729
PMCPMC9020661

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.