Evidence map›Paper›PMID 35442634›Full record

ArticleACS applied materials & interfaces2022

Evaluation of Proton-Induced DNA Damage in 3D-Engineered Glioblastoma Microenvironments.

Qais Akolawala, Marta Rovituso, Henri H Versteeg, Araci M R Rondon, Angelo Accardo

Open access · hybridAbstract read
In one paragraph

Article in ACS applied materials & interfaces, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 34 citations in OpenAlex.

  1. Beyond DNA damage: 3D tumor models and the integrin mechanobiology of radioresistance.Journal of experimental & clinical cancer research : CR · 2026
    Review
  2. Article
  3. PARP9-PARP13-PARP14 axis tunes colorectal cancer response to radiotherapy.Journal of experimental & clinical cancer research : CR · 2025
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Remotely Controlled 3D-Engineered Scaffolds for Biomimetic In Vitro Investigations on Brain Cell Cocultures.Advanced intelligent systems (Weinheim an der Bergstrasse, Germany) · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Neural regeneration research · 2023
    Article
  13. Review
  14. Article
  15. Article
  16. 3D models of glioblastoma interaction with cortical cells.Frontiers in bioengineering and biotechnology · 2023
    Article
  17. Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Qais AkolawalaDepartment of Precision and Microsystems Engineering, Delft University of Technology, Mekelweg 2, 2628 CD Delft, The Netherlands.
Marta RovitusoHolland Proton Therapy Center (HollandPTC), Huismansingel 4, 2629 JH Delft, The Netherlands.
Henri H VersteegEinthoven Laboratory for Vascular and Regenerative Medicine, Division of Thrombosis and Hemostasis, Department of Internal Medicine, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Araci M R RondonEinthoven Laboratory for Vascular and Regenerative Medicine, Division of Thrombosis and Hemostasis, Department of Internal Medicine, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0002-2703-8805
Angelo AccardoDepartment of Precision and Microsystems Engineering, Delft University of Technology, Mekelweg 2, 2628 CD Delft, The Netherlands.ORCID 0000-0003-0442-3652
Delft University of Technology · NLLeiden University Medical Center · NLHuisman (Netherlands) · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma (GBM) is a devastating cancer of the brain with an extremely poor prognosis. For this reason, besides clinical and preclinical studies, novel

Indexed as

Brain NeoplasmsGlioblastomaProton TherapyCell Line, TumorDNA DamageHumansProtonsRadiation, IonizingTumor MicroenvironmentProtonscancerDNA damageengineered cell microenvironmentsglioblastomaproton therapytwo-photon polymerization

Identifiers

PMID35442634
PMCPMC9100514
OpenAlexW4224282038

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.