ArticleAging clinical and experimental research2022
Prediction of post-stroke cognitive impairment by Montreal Cognitive Assessment (MoCA) performances in acute stroke: comparison of three normative datasets.
Article in Aging clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Predicting Long-Term Cognitive Impairments in Survivors after Cardiac Arrest: A Systematic Review.Journal of rehabilitation medicine · 2023Pooled it
- Improving the quality of life and resilience of family caregivers of stroke survivors through education based on the Roy's adaptation model: a randomized controlled trial.Aging clinical and experimental research · 2025Trial
- Utility of Tablet-Based Eye Tracking for Early Screening of Poststroke Cognitive Impairment: Diagnostic Cohort Study.JMIR mHealth and uHealth · 2026Article
- Automated volume estimate of the brain's lateral ventricles reveals a persistent association with cognitive performance among stroke survivors.Cerebral circulation - cognition and behavior · 2026Article
- Sex-related differences in the applicability and performance of the Montreal Cognitive Assessment in the acute phase of stroke.European stroke journal · 2026Article
- Impact of Stroke History on Cognitive Function, White Matter Hyperintensities, and Circulating BDNF Levels.Archives of Iranian medicine · 2025Article
- Development of a Diagnostic Prediction Model for Post-Stroke Cognitive Impairment in Acute Large Vessel Occlusion Stroke Using Multimodal MRI and PET/CT: A Study Protocol.Brain and behavior · 2025Article
- Magnetic Resonance Imaging Study on Older Patients with Cognitive Impairment and Depression.Current medical imaging · 2025Article
- Review
- Potential challenges to harmonize post-stroke cognitive assessment and its prognostic value: a narrative review.Journal of medicine and life · 2024Review
- Improving diagnostic accuracy of the Montreal Cognitive Assessment to identify post-stroke cognitive impairment.Scientific reports · 2024Observational
- Psychometrics and diagnostics of the Italian version of the Alternate Verbal Fluency Battery (AVFB) in non-demented Parkinson's disease patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Therapeutic effectiveness of Donepezil hydrochloride in combination with butylphthalide for post-stroke cognitive impairment.American journal of translational research · 2024Article
- On the Clinimetrics of the Montreal Cognitive Assessment: Cutoff Analysis in Patients with Mild Cognitive Impairment due to Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2024Article
- Validity and diagnostics of the Italian version of the Montreal Cognitive Assessment (MoCA) in non-demented Parkinson's disease patients.Aging clinical and experimental research · 2023Article
- Circulating Serum VEGF, IGF-1 and MMP-9 and Expression of Their Genes as Potential Prognostic Markers of Recovery in Post-Stroke Rehabilitation-A Prospective Observational Study.Brain sciences · 2023Article
- Serum lipidomic alterations associated with post-stroke cognitive impairment: an exploratory prospective study.Frontiers in neurologyArticle
- Outcome of Ischemic Stroke at Six Months with Neuroglobin as a Marker.Innovations in clinical neuroscienceArticle
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCognitive assessment in acute stroke is relevant for identifying patients at risk of persistent post-stroke cognitive impairment (PSCI). Despite preliminary evidence on MoCA accuracy, there is no consensus on its optimal score in the acute stroke setting to predict PSCI.
aims(1) To explore whether the application of different normative datasets to MoCA scores obtained in the acute stroke setting results in variable frequency of patients defined as cognitively impaired; (2) to assess whether the normality cut-offs provided by three normative datasets predict PSCI at 6-9 months; (3) to calculate alternative MoCA cut-offs able to predict PSCI.
methodsConsecutive stroke patients were reassessed at 6-9 months with extensive neuropsychological and functional batteries for PSCI determination.
resultsOut of 207 enrolled patients, 118 (57%) were followed-up (mean 7.4 ± 1.7 months), and 77 of them (65%) received a PSCI diagnosis. The application of the normality thresholds provided by the 3 normative datasets yielded to variable (from 28.5% to 41%) rates of patients having an impaired MoCA performance, and to an inadequate accuracy in predicting PSCI, maximizing specificity instead of sensitivity. In ROC analyses, a MoCA score of 22.82, adjusted according to the most recent normative dataset, achieved a good diagnostic accuracy in predicting PSCI.
conclusionsThe classification of acute stroke patients as normal/impaired based on MoCA thresholds proposed by general population normative datasets underestimated patients at risk of persistent PSCI. We calculated a new adjusted MoCA score predictive of PSCI in acute stroke patients to be further tested in larger studies.
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