Evidence map›Paper›PMID 35441926›Full record

Trial reportCardiovascular drugs and therapy2023

Results from the "Me & My Heart" (eMocial) Study: a Randomized Evaluation of a New Smartphone-Based Support Tool to Increase Therapy Adherence of Patients with Acute Coronary Syndrome.

Florian Krackhardt, Magnus Jörnten-Karlsson, Matthias Waliszewski, Mikael Knutsson, Anna Niklasson, Karl-Friedrich Appel, Ralf Degenhardt, Alexander Ghanem, Till Köhler, Marc-Alexander Ohlow and 5 more

2 registry-linked trialsAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Cardiovascular drugs and therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02615704 completednot on this map

Evaluation of an Electronic Device Based Support Tool for ACS Patients: Brilique (Ticagrelor) Treatment Adherence (eMocial)

TypeobservationalSponsorAstraZenecaRan2016 to 2019Enrolled677ConditionsAcute Coronary SyndromeArmsActive group with MEMS, Active group without MEMS, Control group with MEMS, Control group without MEMS
NCT06882044 nacompletednot on this map

The Effect of a Mobile Application on Treatment Adherence, Self-Management, and Quality of Life in Patients With Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

TypeinterventionalSponsorTrakya UniversityRan2021 to 2024Enrolled61ConditionsAcute Myocardial Infarction (AMI), Mobile Health Technology (mHealth), Quality of Lifte, Treatment AdherenceArmsmHealth
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Florian KrackhardtDepartment of Internal Medicine and Cardiology, Charité Campus Virchow-Klinikum, Charité University Medicine Berlin, Augustenburger Platz 1, 13353, Berlin, Germany. florian.krackhardt@charite.de.ORCID http://orcid.org/0000-0001-5965-8817
Magnus Jörnten-KarlssonDigital Implementation, Digital Health R&D, AstraZeneca, Gothenburg, Sweden.
Matthias WaliszewskiDepartment of Internal Medicine and Cardiology, Charité Campus Virchow-Klinikum, Charité University Medicine Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Mikael KnutssonLate Stage Development, Cardiovascular, Renal, and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Anna NiklassonLate Stage Development, Cardiovascular, Renal, and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Karl-Friedrich AppelAmbulantes Herzzentrum Kassel, Kassel, Germany.
Ralf DegenhardtHerz-Kreislauf-Zentrum, Rotenburg a. d. Fulda, Germany.
Alexander GhanemAsklepios Klinik St. Georg, Hamburg, Germany.
Till KöhlerHerzzentrum Wuppertal, Helios-Universitätsklinikum, Wuppertal, Germany.
Marc-Alexander OhlowSRH-Waldklinikum, Gera, Germany.
Carsten TschöpeBerlin Institute of Health at Charité; BIH Center for Regenerative Therapies (BCRT), Charité-Universitätsmedizin Berlin, Berlin, Germany.
Heinz TheresMartin Luther Krankenhaus, Berlin, Germany.
Jürgen Vom DahlKliniken Maria Hilf, Mönchengladbach, Germany.
Björn W KarlsonLate Stage Development, Cardiovascular, Renal, and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Lars S MaierDepartment of Internal Medicine II, Universitätsklinikum Regensburg, Regensburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study evaluated whether patient support, administered via an electronic device-based app, increased adherence to treatment and lifestyle changes in patients with acute coronary syndrome (ACS) treated with ticagrelor in routine clinical practice.

methodsPatients (aged ≥ 18 years) with diagnosed ACS treated with ticagrelor co-administered with low-dose acetylsalicylic acid were randomized into an active group (with support tool app for medication intake reminders and motivational messages) and a control group (without support tool app), and observed for 48 weeks (ClinicalTrials.gov Identifier: NCT02615704). Patients were asked to complete the 36-item Short-Form Health Survey (SF-36) and Lifestyle Changes Questionnaire (LSQ), and were assessed for blood pressure and body mass index (BMI) at baseline (visit 1) and at the end of the study (visit 2). Medication adherence was measured using the Brilique Adherence Questionnaire (BAQ).

resultsPatients (N = 676) were randomized to an active (n = 342) or a control (n = 334) group. BAQ data were available for 174 patients in the active group and 174 patients in the control group. Over the 48-week period, mean (standard deviation) adherence for the active and control groups was 96.4% (13.2%) and 91.5% (23.1%), respectively (effect of app intervention, p < 0.05). There were no significant differences in blood pressure and BMI between visits. General improvements in SF-36 and LSQ scores were observed for both groups.

conclusionThe patient support tool app was associated with significant improvements in patient-reported treatment adherence compared with a data collection app alone in patients prescribed ticagrelor for ACS.

Indexed as

Acute Coronary SyndromeSmartphoneAspirinHumansMedication AdherenceTicagrelorAspirinTicagrelorAcute coronary syndromeAdherenceDual antiplatelet therapySmartphone-based supportTicagrelor

Identifiers

PMID35441926
PMCPMC10397150

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.