ArticlePediatric pulmonology2022
Oscillometry: A substitute of spirometry in children with neuromuscular diseases?
Article in Pediatric pulmonology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Factors Associated with Uninterpretable Spirometry During Asthma Screening in Children with Sickle Cell Disease: An Expanded Multicenter Study in French Guiana.Children (Basel, Switzerland) · 2026Article
- Machine learning-based integration of respiratory oscillometry and spirometry for predicting clinical outcomes in spinal muscular atrophy.European journal of pediatrics · 2026Article
- Impulse oscillometry values calibrated against spirometric obstruction in children with suspected asthma.Frontiers in pediatrics · 2026Article
- Effort-independent respiratory monitoring in Duchenne muscular dystrophy: clinical value of impulse oscillometry.European journal of pediatrics · 2025Article
- The use of forced oscillation technique in children with restrictive physiology.Breathe (Sheffield, England) · 2025Article
- Multiple respiratory assessment and thresholds for noninvasive ventilation in adult patients with spinal muscular atrophy.Scientific reports · 2025Article
- Comparative efficacy of risdiplam and nusinersen in Type 2 and 3 spinal muscular atrophy patients: A cohort study using real-world data.Journal of neuromuscular diseases · 2024Article
- Oscillometry in Lung Function Assessment: A Comprehensive Review of Current Insights and Challenges.Cureus · 2023Review
- Oscillometry: A substitute of spirometry in children with neuromuscular diseases?Pediatric pulmonology · 2022Article
- Understanding the fundamentals of oscillometry from a strip of lung tissue.Frontiers in physiology · 2022Review
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSpirometry plays an important role in the assessment of possible respiratory failure in children with neuromuscular diseases (NMDs). However, obtaining reliable spirometry results is a major challenge. We studied the relation between oscillometry and spirometry results. Oscillometry is an easy, noninvasive method to measure respiratory resistance R and reactance X. We hypothesized an increased R and reduced X in patients with more reduced lung function.
methodsIn this prospective single-center study, we included all children with NMDs able to perform spirometry. We consecutively measured R and X at 5, 11, and 19 Hz and (forced) vital capacity, peak expiratory flow. Spearman correlation coefficients and positive and negative predictive values were calculated. Regression curves were estimated.
resultsWe included 148 patients, median age 13 years (interquartile range: 8-16). A negative correlation was found between R and spirometry outcomes (Spearman correlation coefficient [ρ]: -0.5 to -0.6, p < 0.001). A positive correlation was found between X (i.e., less negative outcomes) and spirometry outcomes (ρ: 0.4-0.6, p < 0.001). Highest correlation was found at lower frequencies. Regression analysis showed a nonlinear relation. Measurement of inspiratory and expiratory R and X did not provide added value. Positive predictive values of 80%-85% were found for z-scores of R measured at 5 Hz versus (F)VC ≤ 60%.
conclusionWe found a nonlinear relation between oscillometry and spirometry results with increased R and reduced X in patients with more restrictive lung function decline. Given the difficulties with performing spirometry, oscillometry may be a promising substitute.
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