SynthesisAllergy2022
Risk factors for severe reactions in food allergy: Rapid evidence review with meta-analysis.
Synthesis in Allergy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 133 citations in OpenAlex.
- Risk factors for severe reactions in food allergy: Rapid evidence review with meta-analysis.Allergy · 2022Pooled it
- Review
- Early-Life Biomarkers in Food Allergy Development: A Systematic Review of Immunological and Intestinal Pathways.Biomedicines · 2026Review
- Early Introduction and Other Characteristics in Children With Suspected Severe Peanut or Tree Nut Allergy: Finnish Cohort.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- What elevated epithelial alarmins mean (and don't mean) for food challenge outcomes.Pediatric research · 2026Article
- New Adrenaline Devices for Treating Anaphylaxis: Results of a Joint Survey From the European Anaphylaxis Registry and the Allergy-Vigilance Network.Clinical and translational allergy · 2026Article
- Economic modelling of providing 'spare' adrenaline autoinjectors to all schools to improve the management of anaphylaxis.Archives of disease in childhood · 2026Article
- Meat allergy: Specific reactions to chicken, beef, pork, and alternative protein sources.Asia Pacific allergy · 2026Review
- Hazelnut oral immunotherapy in children: An Italian single-center retrospective cohort study.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Italian Evidence-Based Clinical Recommendations on the Appropriateness of Prescriptions and Diagnostic Tests in Pediatric Allergology: Focus on Anaphylaxis, Drug Allergy and Hymenoptera Venom Allergy.Journal of clinical medicine · 2026Review
- Innovative diagnostic techniques and their clinical implications in food allergy: current clinical practice and future perspectives.Frontiers in allergy · 2026Review
- Bridging innovation and risk: the missing role of validated risk-stratification in IgE-mediated food allergy management.Frontiers in allergy · 2026Review
- Clinical characteristics of anaphylaxis and risk factors for severe reactions in children: a single-center experience.Frontiers in pediatrics · 2026Article
- Clinical and immunological markers of peanut allergy severity and tolerance in children.Frontiers in allergy · 2026Article
- Anaphylaxis and pregnancy: Epidemiology, elicitors, and recurrences.The World Allergy Organization journal · 2025Article
- Pediatrics advances in 2024: choices in allergy, cardiology, critical care, endocrinology, gastroenterology, immunology, infectious diseases, neonatology, nephrology, neurology, nutrition, palliative care respiratory tract illnesses, and social media.Italian journal of pediatrics · 2025Review
- Food Allergy and Foodservice: A Comparative Study of Allergic and Non-Allergic Consumers' Behaviors, Attitudes, and Risk Perceptions.Nutrients · 2025Article
- Lactate in Anaphylaxis: 100 Years On.Sports medicine (Auckland, N.Z.) · 2025Review
- Exercise-Induced Angioedema, Urticaria, and Anaphylaxis-A Narrative Review.Sports (Basel, Switzerland) · 2025Review
- Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 10 institutions in 8 countries.
Funding
Abstract
This rapid review summarizes the most up to date evidence about the risk factors for severe food-induced allergic reactions. We searched three bibliographic databases for studies published between January 2010 and August 2021. We included 88 studies and synthesized the evidence narratively, undertaking meta-analysis where appropriate. Significant uncertainties remain with respect to the prediction of severe reactions, both anaphylaxis and/or severe anaphylaxis refractory to treatment. Prior anaphylaxis, an asthma diagnosis, IgE sensitization or basophil activation tests are not good predictors. Some molecular allergology markers may be helpful. Hospital presentations for anaphylaxis are highest in young children, yet this age group appears at lower risk of severe outcomes. Risk of severe outcomes is greatest in adolescence and young adulthood, but the contribution of risk taking behaviour in contributing to severe outcomes is unclear. Evidence for an impact of cofactors on severity is lacking, although food-dependent exercise-induced anaphylaxis may be an exception. Some medications such as beta-blockers or ACE inhibitors may increase severity, but appear less important than age as a factor in life-threatening reactions. The relationship between dose of exposure and severity is unclear. Delays in symptom recognition and anaphylaxis treatment have been associated with more severe outcomes. An absence of prior anaphylaxis does not exclude its future risk.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.