Evidence map›Paper›PMID 35441605›Full record

ArticleActa bio-medica : Atenei Parmensis2022

Peripheral Arterial Tonometry (EndoPAT)-measured Endothelial Dysfunction in Migraine with Aura children.

Alice Bonuccelli, Claudia Sciarrotta, Maria Grazia Esposito, Vanessa Bianchi, Mario Miccoli, Pasquale Striano, Riccardo D'angelo, Margherita Valiani, Emioli Randazzo, Thomas Foiadelli and 3 more

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Article in Acta bio-medica : Atenei Parmensis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Alice BonuccelliPediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa. al.bonuccelli@gmail.com.
Claudia SciarrottaPediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa. claudiasciarrotta@gmail.com.
Maria Grazia EspositoPediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa. maryagrazya@gmail.com.
Vanessa BianchiPediatric Diabetology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa. bianchi.vanessa@alice.it.
Mario MiccoliDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy. mario.miccoli@med.unipi.it.
Pasquale StrianoPediatric Neurology Unit, Dinogmi, Giannina Gaslini's. Istitute, University of Genoa. strianop@gmail.com.
Riccardo D'angeloPediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa. riccardodangelodietista@gmail.com.
Margherita ValianiPediatric Diabetology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa. margheritavaliani@gmail.com.
Emioli RandazzoPediatric Diabetology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa, Italy. emioli.randazzo@gmail.com.
Thomas FoiadelliPediatric Clinic, IRCCS Policlinico San Matteo Foundation, University of Pavia, Pavia, Italy. t.foiadelli@smatteo.pv.it.
Diego PeroniPediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa, Italy. diego.peroni@unipi.it.
Giovanni FedericoPediatric Diabetology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa, Italy. g.federico@med.unipi.it.
Alessandro OrsiniPediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa, Italy. aorsini.md@gmail.com.
Azienda Ospedaliera Universitaria Pisana · ITIstituto Giannina Gaslini · ITUniversity of Pavia · ITUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe association between Migraine with Aura (MA) and vascular disease has been previously reported. We investigated whether pre-clinical vascular alterations, such as Endothelial Dysfunction, are already present in children and adolescents with Migraine with Aura.

methodsWe retrospectively enrolled 27 patients having Migraine with Aura, aged9 -18 years, and 31 age matched healthy control subjects to evaluateEndothelial Function by Peripheral Arterial Tonometry. This technique measures finger pulse wave amplitude, before and during reactive hyperaemia, and calculates the Augmentation Index (AI) and the Reactive Hyperaemia Index (RHI). We also set-up an Aura Severity Scale to assess disease severity and its relationship with AI and RHI alterations.

resultsAlso if the case-control study resulted only partially as significant, we found there is an inversely proportional relationship between the severity of the migraine measured with Aura Severity Scale and the values of the endoscore (a significantly reduced levels of AI (p-value <0,03) and a marginal reduction of RHI levels (p-value <0,07).

conclusionFurther studies should explore the impact of pre-clinical vascular alterations in children and adolescents with Migraine with Aura.

Indexed as

HyperemiaMigraine with AuraVascular DiseasesAdolescentCase-Control StudiesChildEndothelium, VascularHumansManometryRetrospective Studies

Identifiers

PMID35441605
PMCPMC9179064
OpenAlexW4224301859

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.