Evidence map›Paper›PMID 35441552›Full record

ArticleThe Journal of international medical research2022

Negative correlation between early recovery and lipoprotein-associated phospholipase A2 levels after intravenous thrombolysis.

Yanzheng Li, Wei Wang, Hang Yang, Weiheng Guo, Jingyu Feng, Dejiu Yang, Li Guo, Guojun Tan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yanzheng LiDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province 050000, China.
Wei WangDepartment of Radiotherapy and Chemotherapy, Tangshan People's Hospital, Tangshan, Hebei Province 063000, China.
Hang YangDepartment of Neurology, North China University of Science and Technology Affiliated Hospital, North China University of Science and Technology, Tangshan, Hebei Province 063000, China.
Weiheng GuoDepartment of Statistics, Hebei Medical University, Shijiazhuang, Hebei Province 050000, China.
Jingyu FengDepartment of Neurology, North China University of Science and Technology Affiliated Hospital, North China University of Science and Technology, Tangshan, Hebei Province 063000, China.
Dejiu YangDepartment of Neurology, North China University of Science and Technology Affiliated Hospital, North China University of Science and Technology, Tangshan, Hebei Province 063000, China.
Li GuoDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province 050000, China.
Guojun TanDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province 050000, China.ORCID https://orcid.org/0000-0001-7749-4107
Hebei Medical University · CNNorth China University of Science and Technology · CNTangshan People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveLipoprotein-associated phospholipase A2 (Lp-PLA2) is considered a biomarker for systemic inflammation and the risk of myocardial infarction and stroke. However, little is known about the effect of acute vascular events on marker levels. The purpose of this study was to assess the potential association of early recovery with Lp-PLA2 levels in patients with acute ischemic stroke (AIS) after intravenous thrombolysis (IVT).

methodsForty-three consecutive AIS patients who had their first stroke and were hospitalized within 5 hours of the onset of stroke were enrolled. All patients were treated with IVT using alteplase or urokinase. Plasma Lp-PLA2 levels were measured within 24 hours after IVT. Variables that showed a significant association with Lp-PLA2 in univariate analysis were included in the multivariate ordered logistic regression model.

resultsEarly recovery was associated with Lp-PLA2 levels after IVT, and Lp-PLA2 levels tended to decrease with increased probability of early recovery. This study is the first to report a negative correlation between early recovery and Lp-PLA2 levels after IVT.

conclusionEarly recovery after IVT was negatively correlated with Lp-PLA2 A2 levels.

Indexed as

Ischemic StrokeMyocardial InfarctionStroke1-Alkyl-2-acetylglycerophosphocholine EsteraseBiomarkersHumansRisk FactorsThrombolytic Therapy1-Alkyl-2-acetylglycerophosphocholine EsteraseBiomarkersAcute ischemic strokecardiovascular diseaseearly recanalizationinflammationintravenous thrombolysislipoprotein-associated phospholipase A2National Institute of Health Stroke Scale

Identifiers

PMID35441552
PMCPMC9047848
OpenAlexW4224291370

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.