Evidence map›Paper›PMID 35441406›Full record

SynthesisHead & neck2022

Estimating survival after salvage surgery for recurrent salivary gland cancers: Systematic review.

Giuditta Mannelli, Lara V Comini, Andrea Sacchetto, Roberto Santoro, Giuseppe Spinelli, Pierluigi Bonomo, Isacco Desideri, Paolo Bossi, Ester Orlandi, Giammarco Alderotti and 7 more

Open access · hybridAbstract readSystematic Review
In one paragraph

Synthesis in Head & neck, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Intraparotid node metastasis affects the long-term survival of patients with resectable recurrent parotid gland carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023
    Article
  5. The Therapeutic Landscape of Salivary Gland Malignancies-Where Are We Now?International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 1 country.

Giuditta MannelliDepartment of Experimental and Clinical Medicine, University of Florence, Florence.ORCID 0000-0001-7079-3964
Lara V CominiHead and Neck Oncology and Robotic Surgery, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.ORCID 0000-0002-3639-1504
Andrea SacchettoOtorhinolaryngology-Head and Neck Surgery, Department of Surgery, Dentistry, Gynecology, and Pediatrics, University of Verona, University Hospital of Verona, Verona, Italy.
Roberto SantoroDepartment of Experimental and Clinical Medicine, University of Florence, Florence.
Giuseppe SpinelliDepartment of Maxillo Facial Surgery, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
Pierluigi BonomoRadiation Oncology, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.ORCID 0000-0001-8999-5208
Isacco DesideriRadiation Oncology, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
Paolo BossiDepartment of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, ASST (Azienda Socio Sanitaria Territoriale) Spedali Civili, Brescia, Italy.
Ester OrlandiRadiation Oncology, Clinical Department, National Center for Oncological Hadrontherapy (CNAO), Pavia, Italy.
Giammarco AlderottiDepartment of Statistics, Computer Science, Applications "G. Parenti" (DiSIA), University of Florence, Florence, Italy.
Alessandro FranchiDepartment of Translational Research, School of Medicine, University of Pisa, Pisa, Italy.
Annarita PalombaUnit of Histopathology and Molecular Diagnostics, Careggi University Hospital, Florence, Italy.
Albino EccherPathology Unit, Department of Pathology and Diagnostics, University Hospital of Verona, Verona, Italy.ORCID 0000-0002-9992-5550
Daniele MarchioniOtorhinolaryngology-Head and Neck Surgery, Department of Surgery, Dentistry, Gynecology, and Pediatrics, University of Verona, University Hospital of Verona, Verona, Italy.
Riccardo NociniOtorhinolaryngology-Head and Neck Surgery, Department of Surgery, Dentistry, Gynecology, and Pediatrics, University of Verona, University Hospital of Verona, Verona, Italy.
Cesare PiazzaUnit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili of Brescia, University of Brescia, Brescia, Italy.ORCID 0000-0002-2391-9357
Gabriele MolteniOtorhinolaryngology-Head and Neck Surgery, Department of Surgery, Dentistry, Gynecology, and Pediatrics, University of Verona, University Hospital of Verona, Verona, Italy.
University of Verona · ITAzienda Ospedaliero-Universitaria Careggi · ITUniversity of Florence · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITNational Center for Oncological Hadrontherapy · ITUniversity of Brescia · ITUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recurrent salivary gland carcinomas (RSCs) are poorly characterized and their clinical features and treatment options have not yet been fully described. The goal of this study was to analyze the therapeutic strategies and oncological outcomes of RSC patients through a literature review analysis. This systematic review was performed according to the PRISMA statements. Inclusion criteria for the systematic review were based on the population, intervention, comparison, and outcomes according to (PICO) framework. Two thousand seven hundred and four records were selected and 1817 recurrences were studied. Three hundred and sixty-five patients underwent salvage surgery (20.1%) and their 5-year mortality rate, overall survival and disease-free survival were 35%, 70%, and 42%, respectively. RSCs are aggressive neoplasms with a high rate of distant metastases (28.9%). Salvage surgery can be considered in patients with limited local and/or regional recurrences, even in case of single distant relapse, appearing within the first 3 years of follow-up.

Indexed as

Neoplasm Recurrence, LocalSalivary Gland NeoplasmsDisease-Free SurvivalHumansRetrospective StudiesSalvage Therapyrecurrent salivary cancerrecurrent salivary tumorssalivary cancer failuresalvage surgerysalvage surgery outcomes

Identifiers

PMID35441406
PMCPMC9545583
OpenAlexW4224216181

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.