Evidence map›Paper›PMID 35441347›Full record

ReviewCurrent atherosclerosis reports2022

Next Generation Risk Markers in Preventive Cardio-oncology.

Morgan Lamberg, Andrea Rossman, Alexandra Bennett, Sabrina Painter, Rachel Goodman, James MacLeod, Ragasnehith Maddula, David Rayan, Krishna Doshi, Alexander Bick and 2 more

Open access · greenAbstract readReview
In one paragraph

Review in Current atherosclerosis reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Somatic Mosaic Chromosomal Alterations and Death of Cardiovascular Disease Causes among Cancer Survivors.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Morgan LambergCardio-Oncology Program, Division of Cardiovascular Medicine, Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, USA.ORCID 0000-0002-5962-848X
Andrea RossmanMedical College of Wisconsin, Milwaukee, WI, USA.
Alexandra BennettMedical College of Wisconsin, Milwaukee, WI, USA.
Sabrina PainterDepartment of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
Rachel GoodmanCardio-Oncology Program, Division of Cardiovascular Medicine, Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, USA.
James MacLeodMedical College of Wisconsin, Milwaukee, WI, USA.
Ragasnehith MaddulaMedical College of Wisconsin, Milwaukee, WI, USA.
David RayanCardio-Oncology Program, Division of Cardiovascular Medicine, Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, USA.
Krishna DoshiDepartment of Medicine, Advocate Lutheran General Hospital, Park Ridge, IL, USA.
Alexander BickDivision of Genetic Medicine, Department of Medicine, Vanderbilt University, Nashville, TN, USA.
Simone BaileyPreventive Cardiology, Rochester Regional Health, Rochester, MN, USA.
Sherry-Ann BrownCardio-Oncology & Preventive Cardiology Programs, Division of Cardiovascular Medicine, Medical College of Wisconsin, Milwaukee, WI, USA. shbrown@mcw.edu.
Medical College of Wisconsin · USAdvocate Lutheran General Hospital · USUnity Health System · USUniversity of Wisconsin–Milwaukee · USVanderbilt University · US

Funding

Clinical and Translational Science AwardUL1TR001436 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI FREED, JULIE K · 2015 to 2025
$47.5M
Institutional Career Development CoreKL2TR001438 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI WIDLANSKY, MICHAEL E · 2015 to 2024
$2.9M
Impact of L. plantarum 299v supplementation on endothelial function and inflammation in humans with type 2 diabetesK24HL152143 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI WIDLANSKY, MICHAEL E · 2021 to 2025
$572k
NCATS NIH HHS KL2 TR001438NCATS NIH HHS KL2TR001438NCATS NIH HHS UL1 TR001436NCATS NIH HHS UL1TR001436NHLBI NIH HHS K24 HL152143
6 · The paper itself

Abstract

purpose of reviewCardiovascular disease (CVD) and cancer are the first and second most common causes of death within the USA. It is well established that a diagnosis of cancer increases risk and predisposes the patient to CVD, and vice versa. Despite these associations, cancer is not yet incorporated into current CVD risk calculators, necessitating additional CV risk markers for improved stratification in this at-risk population. In this review, we consider the utility of breast arterial calcification (BAC), coronary artery calcification (CAC), clonal hematopoiesis of indeterminate potential (CHIP), and cancer and cancer treatment in CVD risk assessment. RECENT

findingsThere is evidence supporting the use of BAC, CAC, CHIP, and cancer and cancer treatment for improved CV risk stratification in patients with cancer and those who are being screened for cancer. BAC has been shown to predict CAC, coronary atherosclerotic plaque on coronary CTA, coronary artery stenosis on coronary angiography, and CVD events and accordingly enhances CVD risk stratification beyond the atherosclerotic CVD (ASCVD) risk pooled cohort equation. Additionally, CAC visualized on CT utilized for lung cancer screening, radiation planning, and cancer staging is predictive of coronary artery disease (CAD). Furthermore, CHIP can also be utilized in risk stratification, as the presence of CHIP carries a 40% increase in CV risk independent of traditional CV risk factors. Finally, cancer and many oncologic therapies confer a lifelong increased risk of CVD. We propose an emerging set of tools to be incorporated into the routine continuum of CVD risk assessment in individuals who have been treated for cancer or who are being screened for cancer development. In this review, we discuss BAC, CAC, CHIP, and cancer and cancer treatment as emerging risk markers in cardiovascular health assessment. Their effectiveness in predicting and influencing the burden of CVD will be discussed, along with suggestions on their incorporation into preventive cardio-oncology practice. Future research will focus on short- and long-term CVD outcomes in these populations.

Indexed as

Cardiovascular DiseasesCoronary Artery DiseaseLung NeoplasmsVascular CalcificationCoronary AngiographyEarly Detection of CancerHumansRisk AssessmentRisk FactorsBreast arterial calcificationCancerCardio-oncologyClonal hematopoiesis of indeterminate potentialCoronary artery calcificationPreventionRisk

Identifiers

PMID35441347
PMCPMC10026729
OpenAlexW4224215640

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.