Evidence map›Paper›PMID 35441327›Full record

ArticleCellular and molecular life sciences : CMLS2022

Galectin-3 interferes with tissue repair and promotes cardiac dysfunction and comorbidities in a genetic heart failure model.

Fani Vlachou, Aimilia Varela, Konstantina Stathopoulou, Konstantinos Ntatsoulis, Evgenia Synolaki, Harris Pratsinis, Dimitris Kletsas, Paschalis Sideras, Constantinos H Davos, Yassemi Capetanaki and 1 more

Open access · greenAbstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Fani VlachouCenter of Basic Research, Biomedical Research Foundation Academy of Athens, 11527, Athens, Greece.
Aimilia VarelaCenter of Clinical, Experimental and Translational Research, Biomedical Research Foundation Academy of Athens, 11527, Athens, Greece.
Konstantina StathopoulouCenter of Basic Research, Biomedical Research Foundation Academy of Athens, 11527, Athens, Greece.
Konstantinos NtatsoulisCenter of Basic Research, Biomedical Research Foundation Academy of Athens, 11527, Athens, Greece.
Evgenia SynolakiCenter of Clinical, Experimental and Translational Research, Biomedical Research Foundation Academy of Athens, 11527, Athens, Greece.
Harris PratsinisInstitute of Biosciences and Applications, NCSR Demokritos, 153 41, Athens, Greece.
Dimitris KletsasInstitute of Biosciences and Applications, NCSR Demokritos, 153 41, Athens, Greece.
Paschalis SiderasCenter of Clinical, Experimental and Translational Research, Biomedical Research Foundation Academy of Athens, 11527, Athens, Greece.
Constantinos H DavosCenter of Clinical, Experimental and Translational Research, Biomedical Research Foundation Academy of Athens, 11527, Athens, Greece.
Yassemi CapetanakiCenter of Basic Research, Biomedical Research Foundation Academy of Athens, 11527, Athens, Greece.
Stelios PsarrasCenter of Basic Research, Biomedical Research Foundation Academy of Athens, 11527, Athens, Greece. spsarras@bioacademy.gr.ORCID http://orcid.org/0000-0002-7117-7693
Academy of Athens · GRNational Centre of Scientific Research "Demokritos" · GR

Funding

General Secretariat for Research and Technology Synergasia ESPA 09SYN-21-965Hellenic Cardiological Society 2010-13/151
6 · The paper itself

Abstract

Galectin-3, a biomarker for heart failure (HF), has been associated with myocardial fibrosis. However, its causal involvement in HF pathogenesis has been questioned in certain models of cardiac injury-induced HF. To address this, we used desmin-deficient mice (des

Indexed as

CardiomyopathiesEmphysemaHeart FailureAnimalsDesminFibrosisGalectin 3InflammationMiceMice, Inbred C57BLMyocardiumMyocytes, CardiacVentricular RemodelingDesminGalectin 3Cell proliferationFailing heartGalectinsMacrophage–fibroblast cross-talkPro-fibrotic response

Identifiers

PMID35441327
PMCPMC11072767
OpenAlexW4224251120

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.