Evidence map›Paper›PMID 35441167›Full record

ArticlebioRxiv : the preprint server for biology2022

Hippo Signaling Pathway Activation during SARS-CoV-2 Infection Contributes to Host Antiviral Response.

Gustavo Garcia, Yijie Wang, Joseph Ignatius Irudayam, Arjit Vijey Jeyachandran, Sebastian Castillo Cario, Chandani Sen, Shen Li, Yunfeng Li, Ashok Kumar, Karin Nielsen-Saines and 7 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 2 countries.

Gustavo GarciaDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA.
Yijie WangDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA.
Joseph Ignatius IrudayamDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA.
Arjit Vijey JeyachandranDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA.
Sebastian Castillo CarioDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA.
Chandani SenUCLA Children's Discovery and Innovation Institute, Mattel Children's Hospital UCLA, Department of Pediatrics, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA.
Shen LiDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA.
Yunfeng LiTranslational Pathology Core Laboratory, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA.
Ashok KumarDepartment of Ophthalmology, Visual and Anatomical Sciences, Wayne State University, Detroit, MI USA.
Karin Nielsen-SainesUCLA Children's Discovery and Innovation Institute, Mattel Children's Hospital UCLA, Department of Pediatrics, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA.
Samuel W FrenchJonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA.
Priya S ShahDepartment of Chemical Engineering, University of California, Davis, CA 95616, USA.
Kouki MorizonoDivision of Hematology and Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Brigitte GompertsUCLA Children's Discovery and Innovation Institute, Mattel Children's Hospital UCLA, Department of Pediatrics, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA.
Arjun DebDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA.
Arunachalam RamaiahTata Institute for Genetics and Society, Centre at inStem, Bangalore, KA 560065, India.
Vaithilingaraja ArumugaswamiDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA.
University of California, Los Angeles · USMattel Children's Hospital · USCalifornia NanoSystems Institute · USUCLA Jonsson Comprehensive Cancer CenterUniversity of California, Davis · USUniversity of California, Irvine · USWayne State University · US

Funding

Viral Immunology CoreU19AI149504 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHEN, IRVIN S.Y., KITCHEN, SCOTT G · 2020 to 2024
$14.3M
Metabolic and epigenetic reprogramming of vital organs in SARS-CoV-2 induced systemic toxicityR01DK132735 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARUMUGASWAMI, VAITHILINGARAJA, DEB, ARJUN · 2021 to 2023
$6.0M
Interplay between AMPK and Hippo Signaling Regulates Ocular Antiviral Response to Zika virus infectionR01EY032149 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Vaithilingaraja Arumugaswami, Ashok Kumar · 2021 to 2026
$2.8M
B-cell-specific transduction for anti-HIV antibody and B-cell receptor expressionR01AI145044 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MORIZONO, KOKI · 2019 to 2023
$1.9M
Developing a targeted chemoprevention strategy for Non-Small Cell Lung CancerR01CA208303 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GOMPERTS, BRIGITTE N · 2016 to 2020
$1.9M
Impact of Seasonal Variation in Hematocrit, NOx & ET-1 on Vascular ReactivityR21NR010361 · NINR · UNIVERSITY OF MISSOURI-COLUMBIA · PI WIPKE-TEVIS, DEIDRE D · 2008 to 2009
$401k
NCI NIH HHS R01 CA208303NEI NIH HHS R01 EY032149NIAID NIH HHS R01 AI145044NIAID NIH HHS U19 AI149504NIDDK NIH HHS R01 DK132735NINR NIH HHS R21 NR010361
6 · The paper itself

Abstract

SARS-CoV-2, responsible for the COVID-19 pandemic, causes respiratory failure and damage to multiple organ systems. The emergence of viral variants poses a risk of vaccine failures and prolongation of the pandemic. However, our understanding of the molecular basis of SARS-CoV-2 infection and subsequent COVID-19 pathophysiology is limited. In this study, we have uncovered a critical role for the evolutionarily conserved Hippo signaling pathway in COVID-19 pathogenesis. Given the complexity of COVID-19 associated cell injury and immunopathogenesis processes, we investigated Hippo pathway dynamics in SARS-CoV-2 infection by utilizing COVID-19 lung samples, and human cell models based on pluripotent stem cell-derived cardiomyocytes (PSC-CMs) and human primary lung air-liquid interface (ALI) cultures. SARS-CoV-2 infection caused activation of the Hippo signaling pathway in COVID-19 lung and

Identifiers

PMID35441167
PMCPMC9016637
OpenAlexW4224284276

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.