Evidence map›Paper›PMID 35441143›Full record

ArticleRSC chemical biology2022

Synthesis of 4-thiouridines with prodrug functionalization for RNA metabolic labeling.

Sarah Moreno, Melanie Brunner, Isabel Delazer, Dietmar Rieder, Alexandra Lusser, Ronald Micura

Abstract read
In one paragraph

Article in RSC chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sarah MorenoInstitute of Organic Chemistry, Center for Molecular Biosciences Innsbruck, University of Innsbruck Innrain 80-82 6020 Innsbruck Austria ronald.micura@uibk.ac.at.
Melanie BrunnerInstitute of Molecular Biology, Biocenter, Medical University of Innsbruck Innrain 80-82 6020 Innsbruck Austria alexandra.lusser@i-med.ac.at.
Isabel DelazerInstitute of Molecular Biology, Biocenter, Medical University of Innsbruck Innrain 80-82 6020 Innsbruck Austria alexandra.lusser@i-med.ac.at.ORCID https://orcid.org/0000-0003-0388-2304
Dietmar RiederInstitute of Bioinformatics, Biocenter, Medical University of Innsbruck Innrain 82 6020 Innsbruck Austria.ORCID https://orcid.org/0000-0003-1754-690X
Alexandra LusserInstitute of Molecular Biology, Biocenter, Medical University of Innsbruck Innrain 80-82 6020 Innsbruck Austria alexandra.lusser@i-med.ac.at.ORCID https://orcid.org/0000-0002-2226-9081
Ronald MicuraInstitute of Organic Chemistry, Center for Molecular Biosciences Innsbruck, University of Innsbruck Innrain 80-82 6020 Innsbruck Austria ronald.micura@uibk.ac.at.ORCID https://orcid.org/0000-0003-2661-6105

Funding

Austrian Science Fund FWF P 31691Austrian Science Fund FWF P 33936
6 · The paper itself

Abstract

Metabolic labeling has emerged as a powerful tool to endow RNA with reactive handles allowing for subsequent chemical derivatization and processing. Recently, thiolated nucleosides, such as 4-thiouridine (4sU), have attracted great interest in metabolic labeling-based RNA sequencing approaches (TUC-seq, SLAM-seq, TimeLapse-seq) to study cellular RNA expression and decay dynamics. For these and other applications (

Identifiers

PMID35441143
PMCPMC8985182

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.