Evidence map›Paper›PMID 35441137›Full record

ArticleBrain communications2022

Altered spontaneous cortical activity predicts pain perception in individuals with cerebral palsy.

Michael P Trevarrow, Anna Reelfs, Lauren R Ott, Samantha H Penhale, Brandon J Lew, Jessica Goeller, Tony W Wilson, Max J Kurz

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Incidence and risk factors for care-related pain in children with physical disabilities.European journal of physical and rehabilitation medicine · 2023
    Observational
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Michael P TrevarrowInstitute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE 68010, USA.ORCID https://orcid.org/0000-0003-0641-0601
Anna ReelfsInstitute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE 68010, USA.
Lauren R OttInstitute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE 68010, USA.
Samantha H PenhaleInstitute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE 68010, USA.ORCID https://orcid.org/0000-0002-4478-7015
Brandon J LewInstitute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE 68010, USA.ORCID https://orcid.org/0000-0001-9107-4993
Jessica GoellerDepartment of Anesthesiology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Tony W WilsonInstitute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE 68010, USA.
Max J KurzInstitute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE 68010, USA.
Boys Town · USCreighton University · USUniversity of Nebraska Medical Center · US

Funding

Stress-Induced Aberrations in the Mitochondrial Redox Environment Impact Developing Neural Circuits Supporting Cognitive ControlP20GM144641 · NIGMS · FATHER FLANAGAN'S BOYS' HOME · PI Rachel K. Spooner · 2022 to 2026
$15.1M
NEUROPHYSIOLOGY OF RESPONDERS AND NON-RESPONDERS WITH CEREBRAL PALSYR01HD101833 · NICHD · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KURZ, MAX J · 2020 to 2024
$3.2M
Sensorimotor Learning in Children with Cerebral PalsyR01HD086245 · NICHD · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KURZ, MAX J · 2015 to 2018
$2.1M
Neurophysiology of Pain in Children with Cerebral PalsyR21HD096390 · NICHD · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KURZ, MAX J · 2019 to 2020
$421k
NICHD NIH HHS R01 HD086245NICHD NIH HHS R01 HD101833NICHD NIH HHS R21 HD096390NIGMS NIH HHS P20 GM144641
6 · The paper itself

Abstract

Cerebral palsy is the most common paediatric neurological disorder and results in extensive impairment to the sensorimotor system. However, these individuals also experience increased pain perception, resulting in decreased quality of life. In the present study, we utilized magnetoencephalographic brain imaging to examine whether alterations in spontaneous neural activity predict the level of pain experienced in a cohort of 38 individuals with spastic diplegic cerebral palsy and 67 neurotypical controls. Participants completed 5 min of an eyes closed resting-state paradigm while undergoing a magnetoencephalography recording. The magnetoencephalographic data were then source imaged, and the power within the delta (2-4 Hz), theta (5-7 Hz), alpha (8-12 Hz), beta (15-29 Hz), low gamma (30-59 Hz) and high gamma (60-90 Hz) frequency bands were computed. The resulting power spectral density maps were analysed vertex-wise to identify differences in spontaneous activity between groups. Our findings indicated that spontaneous cortical activity was altered in the participants with cerebral palsy in the delta, alpha, beta, low gamma and high gamma bands across the occipital, frontal and secondary somatosensory cortical areas (all

Indexed as

magnetoencephalographyresting stateSIIsomatosensory

Identifiers

PMID35441137
PMCPMC9014448
OpenAlexW4223978892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.