Evidence map›Paper›PMID 35441089›Full record

ArticleAdvanced materials technologies2022

Point-of-Care Platform for Rapid Multiplexed Detection of SARS-CoV-2 Variants and Respiratory Pathogens.

Alexander Y Trick, Fan-En Chen, Liben Chen, Pei-Wei Lee, Alexander C Hasnain, Heba H Mostafa, Karen C Carroll, Tza-Huei Wang

Open access · greenAbstract read
In one paragraph

Article in Advanced materials technologies, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Alexander Y TrickDepartment of Biomedical Engineering Johns Hopkins University Baltimore MD 21218 USA.ORCID https://orcid.org/0000-0003-3997-9669
Fan-En ChenDepartment of Biomedical Engineering Johns Hopkins University Baltimore MD 21218 USA.ORCID https://orcid.org/0000-0001-6970-4370
Liben ChenDepartment of Mechanical Engineering Johns Hopkins University Baltimore MD 21218 USA.ORCID https://orcid.org/0000-0002-0648-2456
Pei-Wei LeeDepartment of Mechanical Engineering Johns Hopkins University Baltimore MD 21218 USA.ORCID https://orcid.org/0000-0001-7491-4057
Alexander C HasnainDepartment of Biomedical Engineering Johns Hopkins University Baltimore MD 21218 USA.
Heba H MostafaDivision of Medical Microbiology Department of Pathology Johns Hopkins University School of Medicine Baltimore MD 21205 USA.
Karen C CarrollDivision of Medical Microbiology Department of Pathology Johns Hopkins University School of Medicine Baltimore MD 21205 USA.ORCID https://orcid.org/0000-0001-8080-5391
Tza-Huei WangDepartment of Biomedical Engineering Johns Hopkins University Baltimore MD 21218 USA.ORCID https://orcid.org/0000-0002-3540-9354
Johns Hopkins University · US

Funding

Technology development for point-of-care detection and antimicrobial susceptibility testing of Neisseria gonorrhoeaeR01AI138978 · NIAID · JOHNS HOPKINS UNIVERSITY · PI WANG, TZA-HUEI JEFF · 2018 to 2021
$5.1M
A "Culture" Shift: Integrated Bacterial Screening and Antibacterial Susceptibility Test on Microfluidic Digital Array for Bloodstream InfectionsR01AI137272 · NIAID · JOHNS HOPKINS UNIVERSITY · PI WANG, TZA-HUEI JEFF, YANG, SAMUEL · 2018 to 2022
$3.6M
Streamlined 15-min HIV Viral Load Self-Testing Using Finger-Stick BloodR61AI154628 · NIAID · JOHNS HOPKINS UNIVERSITY · PI HSIEH, YU-HSIANG, MANABE, YUKARI C · 2020 to 2022
$1.4M
NIAID NIH HHS R01 AI137272NIAID NIH HHS R01 AI138978NIAID NIH HHS R61 AI154628
6 · The paper itself

Abstract

The rise of highly transmissible SARS-CoV-2 variants brings new challenges and concerns with vaccine efficacy, diagnostic sensitivity, and public health responses to end the pandemic. Widespread detection of variants is critical to inform policy decisions to mitigate further spread, and postpandemic multiplexed screening of respiratory viruses will be necessary to properly manage patients presenting with similar respiratory symptoms. In this work, a portable, magnetofluidic cartridge platform for automated polymerase chain reaction testing in <30 min is developed. Cartridges are designed for multiplexed detection of SARS-CoV-2 with either identification of variant mutations or screening for Influenza A and B. Moreover, the platform can perform identification of B.1.1.7 and B.1.351 variants and the multiplexed SARS-CoV-2/Influenza assay using archived clinical nasopharyngeal swab eluates and saliva samples. This work illustrates a path toward affordable and immediate testing with potential to aid surveillance of viral variants and inform patient treatment.

Indexed as

magnetofluidicspoint‐of‐carerespiratory virusesSARS‐CoV‐2variant detection

Identifiers

PMID35441089
PMCPMC9011450
OpenAlexW4205576928

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.