ArticleScientific reports2022
Environmental induced transgenerational inheritance impacts systems epigenetics in disease etiology.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Assessing the Carcinogenic Potential of Jet Fuels: A Fit-for-Purpose Systematic Literature Review.Journal of occupational and environmental medicine · 2026Pooled it
- After the Maps: Assessing Longitudinal Neighborhood Change After Historical Redlining with Present-Day Breast Cancer Survival.Journal of urban health : bulletin of the New York Academy of Medicine · 2026Article
- Epigenetic Changes Associated With a Phenotypic Transition in Namibian Cheetahs.Molecular ecology · 2026Article
- Maternal Microbiome in Fetal Programming: A One Health Perspective on Translational Implications for Early-Life Health.Microorganisms · 2026Review
- Built Environment-Modulated Epigenetics: The Epigenetic Consequences of Architecturally Mediated Allostatic Overload in the Built Environment.International journal of environmental research and public health · 2026Review
- Unravelling male infertility through epigenetics: present understanding and future challenges.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Review
- A Review on the Effects of Atrazine on Male Rat Reproductive System Cytoarchitecture, Steroidogenesis and Oxidative Pathway.Journal of molecular histology · 2026Review
- BPA-induced differential methylation of the androgen receptor promoter CpG island in medaka germline and somatic cells.Environmental epigenetics · 2026Article
- Weighted epigenetic site correlation network analysis of chemotherapy impacts on osteosarcoma cancer survivors' male fertility, sperm, and endocrine parameters.Environmental epigenetics · 2026Article
- Methods for Investigating the Sperm Epigenome.Advances in experimental medicine and biology · 2026Review
- Review
- Generational stability of environmentally induced epigenetic transgenerational inheritance of adult-onset disease over ten mammalian generations.Environmental epigenetics · 2025Article
- Genetics, Epigenetics, and the Environment: Are Precision Medicine, Provider Compassion, and Social Justice Effective Public Health Measures to Mitigate Disease Risk and Severity?International journal of environmental research and public health · 2024Review
- Epigenetic transgenerational inheritance of toxicant exposure-specific non-coding RNA in sperm.Environmental epigenetics · 2024Article
- Epigenetic biomarker for preeclampsia-associated preterm birth and potential preventative medicine.Environmental epigenetics · 2024Article
- Epigenome-wide association study of systemic effects of obesity susceptibility in human twins.Epigenetics · 2023Article
- A systematic scientometric review of paternal inheritance of acquired metabolic traits.BMC biology · 2023Review
- Systemic epigenome-wide association study of elk treponeme-associated hoof disease.Scientific reports · 2023Article
- Concern over differences between experimental design and data analyses in Jones et al.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Endocrine disruptors in plastics alter β-cell physiology and increase the risk of diabetes mellitus.American journal of physiology. Endocrinology and metabolism · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Environmental toxicants have been shown to promote the epigenetic transgenerational inheritance of disease through exposure specific epigenetic alterations in the germline. The current study examines the actions of hydrocarbon jet fuel, dioxin, pesticides (permethrin and methoxychlor), plastics, and herbicides (glyphosate and atrazine) in the promotion of transgenerational disease in the great grand-offspring rats that correlates with specific disease associated differential DNA methylation regions (DMRs). The transgenerational disease observed was similar for all exposures and includes pathologies of the kidney, prostate, and testis, pubertal abnormalities, and obesity. The disease specific DMRs in sperm were exposure specific for each pathology with negligible overlap. Therefore, for each disease the DMRs and associated genes were distinct for each exposure generational lineage. Observations suggest a large number of DMRs and associated genes are involved in a specific pathology, and various environmental exposures influence unique subsets of DMRs and genes to promote the transgenerational developmental origins of disease susceptibility later in life. A novel multiscale systems biology basis of disease etiology is proposed involving an integration of environmental epigenetics, genetics and generational toxicology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.