ArticleNature communications2022
Local structure-function relationships in human brain networks across the lifespan.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.
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Who cites it
103 citing papers in PubMed.
- The mediating role of brain structural-functional connectivity coupling in linking paternal education to BMI and depressive scores in young adults.BMC psychiatry · 2026Article
- Brain structural and functional connectivity converge prenatally but diverge after birth.PLoS biology · 2026Article
- Longitudinal Associations of Structural and Functional Brain Connectivity With Dimensions of Psychopathology in Adolescence.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Multiscale brain development across the human lifespan.Communications biology · 2026Review
- DTI-ALPS and subcortical structural-functional coupling mediate the impact of sleep quality on working memory in insomnia disorder.Psychological medicine · 2026Article
- Decreased amyloid-related structure-function coupling in preclinical Alzheimer's disease.Communications medicine · 2026Article
- Developmental changes of the white matter functional connectome.Molecular psychiatry · 2026Article
- Brain maintenance biomarkers from structural and functional interactions in aging and neurodegeneration.Nature communications · 2026Article
- Tract-explainable and underexplained synchrony play complementary roles in the functional organization of the brain.bioRxiv : the preprint server for biology · 2026Article
- Article
- Trait-Relevant Tasks Improve Personality Prediction From Structural-Functional Brain Network Coupling.Human brain mapping · 2026Article
- White matter pathways mediating dorsolateral prefrontal TMS therapy for depression.Nature neuroscience · 2026Article
- Brain functional-structural gradient coupling reflects development, behavior and genetic influences.Nature communications · 2026Article
- Structure-function coupling in the human brainstem.bioRxiv : the preprint server for biology · 2026Article
- Introducing Structural Reliance: A New Method to Assess Structure-Function Coupling in the Brain.Human brain mapping · 2026Article
- The role of white matter myelin in structural-functional network coupling.Communications biology · 2026Article
- Dual-axis myelination covariance drives the functional connectivity emergence during infancy.Nature communications · 2026Article
- Network Disconnection Syndrome in Unruptured Brain Arteriovenous Malformations: A Multimodal Connectome Study.CNS neuroscience & therapeutics · 2026Article
- Synapse types are spatially associated with regional hemodynamics in the mouse brain.PLoS biology · 2026Article
- Variation in high-amplitude events across the human lifespan.Network neuroscience (Cambridge, Mass.) · 2026Article
43 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
A growing number of studies have used stylized network models of communication to predict brain function from structure. Most have focused on a small set of models applied globally. Here, we compare a large number of models at both global and regional levels. We find that globally most predictors perform poorly. At the regional level, performance improves but heterogeneously, both in terms of variance explained and the optimal model. Next, we expose synergies among predictors by using pairs to jointly predict FC. Finally, we assess age-related differences in global and regional coupling across the human lifespan. We find global decreases in the magnitude of structure-function coupling with age. We find that these decreases are driven by reduced coupling in sensorimotor regions, while higher-order cognitive systems preserve local coupling with age. Our results describe patterns of structure-function coupling across the cortex and how this may change with age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.