Evidence map›Paper›PMID 35440586›Full record

ArticleNature communications2022

Single cell analyses identify a highly regenerative and homogenous human CD34+ hematopoietic stem cell population.

Fernando Anjos-Afonso, Florian Buettner, Syed A Mian, Hefin Rhys, Jimena Perez-Lloret, Manuel Garcia-Albornoz, Namrata Rastogi, Linda Ariza-McNaughton, Dominique Bonnet

Abstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Article
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  4. Review
  5. Article
  6. ATP2B1 expression identifies human hematopoietic stem cells with superior repopulation and self-renewal.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. FACS-Based Assessment of Human Hematopoietic Stem and Progenitor Cells.International journal of molecular sciences · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Targeted knock-in ofMolecular therapy. Nucleic acids · 2024
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fernando Anjos-Afonso *Haematopoietic Signalling Group, European Cancer Stem Cell Institute, School of Biosciences, Cardiff University, Cardiff, UK. dosanjosafonsof@cardiff.ac.uk.ORCID 0000-0003-4392-488X
Florian BuettnerGerman Cancer Research Center (DKFZ), Heidelberg, Germany.
Syed A MianHaematopoietic Stem Cell Lab, The Francis Crick Institute, London, UK.ORCID 0000-0001-8005-2860
Hefin RhysFlow Cytometry Facility, The Francis Crick Institute, London, UK.ORCID 0000-0002-7385-9014
Jimena Perez-LloretAdvance Sequencing Facility, The Francis Crick Institute, London, UK.
Manuel Garcia-AlbornozHaematopoietic Stem Cell Lab, The Francis Crick Institute, London, UK.ORCID 0000-0002-2300-2047
Namrata RastogiHaematopoietic Signalling Group, European Cancer Stem Cell Institute, School of Biosciences, Cardiff University, Cardiff, UK.
Linda Ariza-McNaughtonHaematopoietic Stem Cell Lab, The Francis Crick Institute, London, UK.
Dominique Bonnet *Haematopoietic Stem Cell Lab, The Francis Crick Institute, London, UK. dominique.bonnet@crick.ac.uk.ORCID 0000-0002-4735-5226

Funding

Biotechnology and Biological Sciences Research Council BB/S017097/1Cancer Research UK FC00010045Medical Research Council FC0010045Wellcome Trust FC00010045Wellcome Trust FC001045
6 · The paper itself

Abstract

The heterogeneous nature of human CD34

Indexed as

Hematopoietic Stem CellsSingle-Cell AnalysisAntigens, CD34Cell Adhesion MoleculesCell LineageEndothelial Protein C ReceptorHumansAntigens, CD34Cell Adhesion MoleculesEndothelial Protein C Receptor

Identifiers

PMID35440586
PMCPMC9018830

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.