ArticleNPJ Parkinson's disease2022
Toward therapeutic electrophysiology: beta-band suppression as a biomarker in chronic local field potential recordings.
Article in NPJ Parkinson's disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07244549 (Chronic Neurophyhsiological and Kinematic Biomarker Monitoring in Patients With Dystonia and Pallidal Deep Brain Stimulation), which is not on this map. Cited by 57 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Chronic Neurophyhsiological and Kinematic Biomarker Monitoring in Patients With Dystonia and Pallidal Deep Brain Stimulation
Who cites it
57 citing papers in PubMed, 123 citations in OpenAlex.
- Chronic adaptive deep brain stimulation versus conventional stimulation in Parkinson's disease: a blinded randomized feasibility trial.Nature medicine · 2024Trial
- Stimulation and Medication Effects on Subthalamic Nucleus Beta-Band Power in Parkinson's Disease: Implications for Adaptive Deep Brain Stimulation.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Activity-dependent adaptive deep brain stimulation improves gait in Parkinson's disease.Nature medicine · 2026Article
- Transcranial focused ultrasound modulates spiking, LFP, and BOLD activity in the primate thalamus.Nature communications · 2026Article
- Adaptive Deep Brain Stimulation for Parkinson's Disease: Navigating the Roadblocks to Clinical Implementation.Movement disorders : official journal of the Movement Disorder Society · 2026Review
- Nonmotor Symptoms in Parkinson's Disease: Neurophysiology Biomarkers and Neuromodulation Approaches.Stereotactic and functional neurosurgery · 2026Review
- Cortical and basal ganglia beta oscillations and frequency-dependent DBS effects in the A53T Parkinson's disease rat model.NPJ Parkinson's disease · 2026Article
- Advanced Therapeutics in Parkinson's Disease: What's New?Current neurology and neuroscience reports · 2026Review
- Low-frequency activity in the subthalamic nucleus informs about the acute neuropsychiatric state in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Video-based machine learning models for predicting deep brain stimulation outcomes in Parkinson's disease patients.NPJ Parkinson's disease · 2026Article
- Excessive daytime sleepiness in parkinsonism is associated with cortical and basal ganglia beta oscillatory activity.Communications biology · 2026Article
- Subthalamic beta activity and neuroimaging concordance in deep brain stimulation: electrode placement and clinical outcomes.Clinical neurophysiology practice · 2026Article
- Article
- Local field potential biomarkers for adaptive deep brain stimulation in Parkinson's disease: A scoping review.Surgical neurology international · 2026Review
- The potential of event-related beta oscillations as biomarkers for neuromodulatory treatment efficacy.Frontiers in psychology · 2026Article
- Wavelet-Based Tremor Quantification From Wrist-Worn Sensor Data in Home-Dwelling People With Parkinson's Disease.IEEE journal of translational engineering in health and medicine · 2026Article
- Designing Neural Dynamics: From Digital Twin Modeling to Regeneration.International journal of molecular sciences · 2025Review
- Local field potentials survey to guide DBS programming in Parkinson's disease: a clinical-neurophysiological longitudinal study.NPJ Parkinson's disease · 2025Article
- Lower limb motor effects of DBS neurofeedback in Parkinson's disease assessed through IMU-based UPDRS movement quality metrics.Scientific reports · 2025Article
- Subthalamic beta peak power ratio as an electrophysiological marker for deep brain stimulation contact selection in Parkinson's disease.Neurological research and practice · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
Abstract
Adaptive deep brain stimulation (aDBS) is a promising concept for feedback-based neurostimulation, with the potential of clinical implementation with the sensing-enabled Percept neurostimulator. We aim to characterize chronic electrophysiological activity during stimulation and to validate beta-band activity as a biomarker for bradykinesia. Subthalamic activity was recorded during stepwise stimulation amplitude increase OFF medication in 10 Parkinson's patients during rest and finger tapping. Offline analysis of wavelet-transformed beta-band activity and assessment of inter-variable relationships in linear mixed effects models were implemented. There was a stepwise suppression of low-beta activity with increasing stimulation intensity (p = 0.002). Low-beta power was negatively correlated with movement speed and predictive for velocity improvements (p < 0.001), stimulation amplitude for beta suppression (p < 0.001). Here, we characterize beta-band modulation as a chronic biomarker for motor performance. Our investigations support the use of electrophysiology in therapy optimization, providing evidence for the use of biomarker analysis for clinical aDBS.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.