SynthesisNature communications2022
CO
Synthesis in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06797661 (Insights Into the Pathophysiology of Neurovascular Uncoupling in Patients with Brain Lesions.), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Insights Into the Pathophysiology of Neurovascular Uncoupling in Patients with Brain Lesions.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- On the mechanisms of brain blood flow regulation during hypoxia.The Journal of physiology · 2025Pooled it
- Hypercapnia dissociates neuronal and hemodynamic responses impairing neurovascular coupling and functional brain connectivity.Nature communications · 2026Article
- Astrocytes: Orchestrators of brain gas exchange and oxygen homeostasis.The Journal of physiology · 2026Review
- Impact of neurovascular coupling and glymphatic function on cognitive function in asymptomatic cerebral small vessel disease.Frontiers in neurology · 2026Article
- Cortical layer multi-parameter analysis of neurovascular impairments in AD/ADRD rodent model with in vivo optical imaging.Translational neurodegeneration · 2025Article
- Carbogen Inhalation Therapy for Epileptic Seizures: Mechanisms, Evidence, and Future Directions.CNS neuroscience & therapeutics · 2025Review
- The pathogenesis of cerebral small vessel disease and vascular cognitive impairment.Physiological reviews · 2025Review
- Cerebral blood flow and energy demand: imaging insights into neurovascular function.Neurophotonics · 2025Review
- Near-lifespan mesoscopic optical imaging of cerebrovascular function reveals age and sex differences in preclinical Alzheimer's disease model.Brain communications · 2025Article
- Endothelial Piezo1 channel mediates mechano-feedback control of brain blood flow.Nature communications · 2024Article
- The Astrocyte: Metabolic Hub of the Brain.Cold Spring Harbor perspectives in biology · 2024Review
- Neurovascular coupling and CONature communications · 2024Article
- Neurovascular coupling during hypercapnia in cerebral blood flow regulation.Nature communications · 2024Article
- Arterial Aging and Cerebrovascular Function: Impact of Aerobic Exercise Training in Older Adults.Aging and disease · 2024Review
- Effects of clamping end-tidal CONMR in biomedicine · 2024Article
- Neurovascular coupling is optimized to compensate for the increase in proton production from nonoxidative glycolysis and glycogenolysis during brain activation and maintain homeostasis of pH, pCOJournal of neurochemistry · 2024Article
- An interaction graph approach to gain new insights into mechanisms that modulate cerebrovascular tone.Communications biology · 2024Review
- Astrocyte Regulation of Cerebral Blood Flow in Health and Disease.Cold Spring Harbor perspectives in biology · 2024Review
- Electro-metabolic signaling.The Journal of general physiology · 2024Article
- Shared Proteins and Pathways of Cardiovascular and Cognitive Diseases: Relation to Vascular Cognitive Impairment.Journal of proteome research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Neurovascular coupling is a fundamental brain mechanism that regulates local cerebral blood flow (CBF) in response to changes in neuronal activity. Functional imaging techniques are commonly used to record these changes in CBF as a proxy of neuronal activity to study the human brain. However, the mechanisms of neurovascular coupling remain incompletely understood. Here we show in experimental animal models (laboratory rats and mice) that the neuronal activity-dependent increases in local CBF in the somatosensory cortex are prevented by saturation of the CO
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.