Evidence map›Paper›PMID 35440502›Full record

ArticleCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2022

Impact of acetaminophen product labelling changes in Canada on hospital admissions for accidental acetaminophen overdose: a population-based study.

Tony Antoniou, Qi Guan, Diana Martins, Tara Gomes

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Tony AntoniouLi Ka Shing Knowledge Institute (Antoniou, Gomes), Unity Health; Department of Family and Community Medicine (Antoniou), Unity Health; Department of Family and Community Medicine (Antoniou), University of Toronto; Ontario Drug Policy Research Network (Antoniou, Martins, Gomes); Institute for Health Policy, Management and Evaluation (Guan, Gomes), University of Toronto; Leslie Dan Faculty of Pharmacy (Gomes), University of Toronto, Toronto, Ont. Tony.antoniou@unityhealth.to.
Qi GuanLi Ka Shing Knowledge Institute (Antoniou, Gomes), Unity Health; Department of Family and Community Medicine (Antoniou), Unity Health; Department of Family and Community Medicine (Antoniou), University of Toronto; Ontario Drug Policy Research Network (Antoniou, Martins, Gomes); Institute for Health Policy, Management and Evaluation (Guan, Gomes), University of Toronto; Leslie Dan Faculty of Pharmacy (Gomes), University of Toronto, Toronto, Ont.
Diana MartinsLi Ka Shing Knowledge Institute (Antoniou, Gomes), Unity Health; Department of Family and Community Medicine (Antoniou), Unity Health; Department of Family and Community Medicine (Antoniou), University of Toronto; Ontario Drug Policy Research Network (Antoniou, Martins, Gomes); Institute for Health Policy, Management and Evaluation (Guan, Gomes), University of Toronto; Leslie Dan Faculty of Pharmacy (Gomes), University of Toronto, Toronto, Ont.
Tara GomesLi Ka Shing Knowledge Institute (Antoniou, Gomes), Unity Health; Department of Family and Community Medicine (Antoniou), Unity Health; Department of Family and Community Medicine (Antoniou), University of Toronto; Ontario Drug Policy Research Network (Antoniou, Martins, Gomes); Institute for Health Policy, Management and Evaluation (Guan, Gomes), University of Toronto; Leslie Dan Faculty of Pharmacy (Gomes), University of Toronto, Toronto, Ont.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccidental acetaminophen overdoses are associated with substantial morbidity and health care costs. In Canada, updated labelling standards were implemented in October 2009 and September 2016, with the intent of communicating risks of overdose and facilitating product identification and safe use, respectively. Full compliance with the 2016 standards was expected by March 2018. We sought to explore whether these changes affected rates of hospital admission for accidental acetaminophen overdose.

methodsWe conducted a population-based study of hospital admissions for accidental acetaminophen overdose in 9 Canadian provinces and 3 Canadian territories between Apr. 1, 2014, and Mar. 31, 2020. We used interventional autoregressive integrated moving average (ARIMA) models to evaluate the impact of the updated labelling standards on rates of hospital admission for accidental acetaminophen overdose. In secondary analyses, we studied intensive care unit (ICU) admissions and hospital admissions for accidental acetaminophen overdose involving opioids.

resultsMonthly rates of hospital admission for accidental acetaminophen overdose were essentially unchanged over the study period (0.21 and 0.22 cases per 100 000 population in April 2004 and March 2020, respectively). We found no association between changing labelling standards and trends in rates of hospital admission for accidental acetaminophen overdose (October 2009

interpretationModifications to product labels did not reduce the rate of acetaminophen-related harm. Additional measures to reduce the burden of accidental acetaminophen overdose are required.

Indexed as

AcetaminophenDrug OverdoseCanadaHospitalsHumansProduct LabelingAcetaminophen

Identifiers

PMID35440502
PMCPMC9028412

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.