ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022
Neurons in the Dorsomedial Hypothalamus Promote, Prolong, and Deepen Torpor in the Mouse.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Using Organoids to Unlock the Potential of Human Torpor for Spaceflight.Current stem cell reports · 2026Article
- Serotype-dependent differences in AAV cellular transduction rates in the hypothalamus of Arctic ground squirrels.Journal of neuroscience methods · 2026Article
- Clocks slide rather than freeze during torpor in the mouse.iScience · 2026Article
- Neural circuits of torpor.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Article
- Article
- Serotype-dependent differences in AAV cellular transduction rates in the hypothalamus of Arctic ground squirrels.bioRxiv : the preprint server for biology · 2026Article
- Inhibition of daily torpor in mice requires calories, not just feeding: a potential role for GLP-1.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Article
- Estrous cycle modulates fasting-induced torpor propensity via hypothalamic estrogen signalling.Scientific reports · 2026Article
- Perspective for Modulation of Hypothalamic Neurogenesis: Integrating Anatomical Insights with Exercise and Dietary Interventions.International journal of molecular sciences · 2025Review
- Biological Mechanisms Balancing Torpor and Reproduction in Mammals.Endocrinology · 2025Review
- Synthetic torpor: advancing metabolic regulation for medical innovations.Nature metabolism · 2025Review
- Spontaneous and pharmacologically induced hypothermia protect mice against endotoxic shock.British journal of pharmacology · 2025Article
- The cold truth: torpor as a confound in studies of caloric restriction.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2025Review
- Cold is hot for slowing aging.Nature aging · 2025Article
- The Art of Chilling Out: How Neurons Regulate Torpor.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Inhibition of the hypothalamic ventromedial periventricular area activates a dynorphin pathway-dependent thermoregulatory inversion in rats.Current biology : CB · 2025Article
- Hypothalamic neural circuits regulating energy expenditure.Vitamins and hormones · 2025Review
- Donepezil Nanoemulsion Induces a Torpor-like State with Reduced Toxicity in NonhibernatingACS nano · 2024Article
- A torpor-like state (TLS) in mice slows blood epigenetic aging and prolongs healthspan.bioRxiv : the preprint server for biology · 2024Article
- Neural circuits of long-term thermoregulatory adaptations to cold temperatures and metabolic demands.Nature reviews. Neuroscience · 2024Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Torpor is a naturally occurring, hypometabolic, hypothermic state engaged by a wide range of animals in response to imbalance between the supply and demand for nutrients. Recent work has identified some of the key neuronal populations involved in daily torpor induction in mice, in particular, projections from the preoptic area of the hypothalamus to the dorsomedial hypothalamus (DMH). The DMH plays a role in thermoregulation, control of energy expenditure, and circadian rhythms, making it well positioned to contribute to the expression of torpor. We used activity-dependent genetic TRAPing techniques to target DMH neurons that were active during natural torpor bouts in female mice. Chemogenetic reactivation of torpor-TRAPed DMH neurons in calorie-restricted mice promoted torpor, resulting in longer and deeper torpor bouts. Chemogenetic inhibition of torpor-TRAPed DMH neurons did not block torpor entry, suggesting a modulatory role for the DMH in the control of torpor. This work adds to the evidence that the preoptic area of the hypothalamus and the DMH form part of a circuit within the mouse hypothalamus that controls entry into daily torpor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.