Evidence map›Paper›PMID 35440204›Full record

ArticleJournal of the Royal Society, Interface2022

Wide-range viscoelastic compression forces in microfluidics to probe cell-dependent nuclear structural and mechanobiological responses.

Maria Isabella Maremonti, Valeria Panzetta, David Dannhauser, Paolo Antonio Netti, Filippo Causa

Abstract read
In one paragraph

Article in Journal of the Royal Society, Interface, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maria Isabella MaremontiInterdisciplinary Research Centre on Biomaterials (CRIB) and Dipartimento di Ingegneria Chimica, dei Materiali e della Produzione Industriale, Università degli Studi di Napoli 'Federico II', Piazzale Tecchio 80, 80125 Naples, Italy.ORCID 0000-0003-1170-3425
Valeria PanzettaInterdisciplinary Research Centre on Biomaterials (CRIB) and Dipartimento di Ingegneria Chimica, dei Materiali e della Produzione Industriale, Università degli Studi di Napoli 'Federico II', Piazzale Tecchio 80, 80125 Naples, Italy.ORCID 0000-0001-6174-4116
David DannhauserInterdisciplinary Research Centre on Biomaterials (CRIB) and Dipartimento di Ingegneria Chimica, dei Materiali e della Produzione Industriale, Università degli Studi di Napoli 'Federico II', Piazzale Tecchio 80, 80125 Naples, Italy.ORCID 0000-0003-3324-9841
Paolo Antonio NettiInterdisciplinary Research Centre on Biomaterials (CRIB) and Dipartimento di Ingegneria Chimica, dei Materiali e della Produzione Industriale, Università degli Studi di Napoli 'Federico II', Piazzale Tecchio 80, 80125 Naples, Italy.ORCID 0000-0002-2435-7181
Filippo CausaInterdisciplinary Research Centre on Biomaterials (CRIB) and Dipartimento di Ingegneria Chimica, dei Materiali e della Produzione Industriale, Università degli Studi di Napoli 'Federico II', Piazzale Tecchio 80, 80125 Naples, Italy.ORCID 0000-0002-5436-3857

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cell nucleus plays a critical role in mechanosensing and mechanotransduction processes, by adaptive changes of its envelope composition to external biophysical stimuli such as substrate rigidity and tensile forces. Current measurement approaches lack precise control in stress application on nuclei, thus significantly impairing a complete mechanobiological study of cells. Here, we present a contactless microfluidic approach capable to exert a wide range of viscoelastic compression forces (10-10

Indexed as

Lamin Type AMicrofluidicsBiophysicsCell NucleusChromatinMechanotransduction, CellularChromatinLamin Type Amicrofluidic devicenuclear deformationnuclear envelopesingle-cellviscoelastic forces

Identifiers

PMID35440204
PMCPMC9019521

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.