ArticleCirculation research2022
Perivascular Fibrosis Is Mediated by a KLF10-IL-9 Signaling Axis in CD4+ T Cells.
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Article in Circulation research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 23 citations in OpenAlex.
- Molecular Mechanisms of Cardiac Fibrosis: A Pathologist's Perspective.Current issues in molecular biology · 2026Review
- The Transcription Factor DDIT3 Regulates Macrophage Function by Inhibiting KLF10 to Attenuate ALI/ARDS Inflammation.Inflammation · 2026Article
- Th9/IL-9 axis mediates airway fibrosis in traumatic tracheal stenosis via TGF-β1/SMAD2/3 signaling.Respiratory research · 2025Article
- Angiotensin II Promotes Progressive Activation of Fibrogenic Periostin-Lineage Cells in Lung and Kidney.Cells · 2025Article
- PVAT adipocyte: energizing, modulating, and structuring vascular function during normotensive and hypertensive states.American journal of physiology. Heart and circulatory physiology · 2025Review
- Cardiac Fibrosis in the Multi-Omics Era: Implications for Heart Failure.Circulation research · 2025Review
- Immunotherapy for hypertensive end-organ damage: a new therapeutic strategy.Essays in biochemistry · 2025Review
- Complex regulation of cardiac fibrosis: insights from immune cells and signaling pathways.Journal of translational medicine · 2025Review
- Exercise-mediated epigenetic modifications in cardiovascular diseases.Epigenomics · 2025Review
- Immunomodulatory Activity of Cytokines in Hypertension: A Vascular Perspective.Hypertension (Dallas, Tex. : 1979) · 2024Review
- Immune and inflammatory mechanisms in hypertension.Nature reviews. Cardiology · 2024Review
- Locus of (IL-9) control: IL9 epigenetic regulation in cellular function and human disease.Experimental & molecular medicine · 2024Review
- Cardiac and perivascular myofibroblasts, matrifibrocytes, and immune fibrocytes in hypertension; commonalities and differences with other cardiovascular diseases.Cardiovascular research · 2024Review
- Withaferin A as a Potential Therapeutic Target for the Treatment of Angiotensin II-Induced Cardiac Cachexia.Cells · 2024Article
- New Insights into the Role of KLF10 in Tissue Fibrosis.International journal of molecular sciences · 2024Review
- Lactate's impact on immune cells in sepsis: unraveling the complex interplay.Frontiers in immunology · 2024Review
- Anatomical location, sex, and age modulate adipocyte progenitor populations in perivascular adipose tissues.Frontiers in physiology · 2024Article
- Impaired cardiac pump function assessment with normalized cardiac power using cardiac magnetic resonance in patients with hypertrophic cardiomyopathy.Quantitative imaging in medicine and surgery · 2023Article
- Macrophage Dectin-1 mediates Ang II renal injury through neutrophil migration and TGF-β1 secretion.Cellular and molecular life sciences : CMLS · 2023Article
- Single-cell RNA sequencing reveals cell subpopulations in the tumor microenvironment contributing to hepatocellular carcinoma.Frontiers in cell and developmental biology · 2023Article
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Authors and funding
16 authors at 3 institutions in 3 countries.
Rulin Zhuang *Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (R.Z., J.C., H.S.C., C.A., A.J., A.K.P., D.P.-C., B.Z., A.T., A.K.W., J.P., M.W.F.).
Jingshu Chen *Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (R.Z., J.C., H.S.C., C.A., A.J., A.K.P., D.P.-C., B.Z., A.T., A.K.W., J.P., M.W.F.).
Henry S Cheng *Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (R.Z., J.C., H.S.C., C.A., A.J., A.K.P., D.P.-C., B.Z., A.T., A.K.W., J.P., M.W.F.).
Carmel AssaDepartment of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (R.Z., J.C., H.S.C., C.A., A.J., A.K.P., D.P.-C., B.Z., A.T., A.K.W., J.P., M.W.F.).
Anurag JamaiyarDepartment of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (R.Z., J.C., H.S.C., C.A., A.J., A.K.P., D.P.-C., B.Z., A.T., A.K.W., J.P., M.W.F.).ORCID 0000-0002-8731-2394
Arvind K PandeyDepartment of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (R.Z., J.C., H.S.C., C.A., A.J., A.K.P., D.P.-C., B.Z., A.T., A.K.W., J.P., M.W.F.).
Daniel Pérez-CremadesDepartment of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (R.Z., J.C., H.S.C., C.A., A.J., A.K.P., D.P.-C., B.Z., A.T., A.K.W., J.P., M.W.F.).ORCID 0000-0002-0969-8762
Bofang ZhangDepartment of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (R.Z., J.C., H.S.C., C.A., A.J., A.K.P., D.P.-C., B.Z., A.T., A.K.W., J.P., M.W.F.).
Aspasia TzaniDepartment of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (R.Z., J.C., H.S.C., C.A., A.J., A.K.P., D.P.-C., B.Z., A.T., A.K.W., J.P., M.W.F.).
Akm Khyrul WaraDepartment of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (R.Z., J.C., H.S.C., C.A., A.J., A.K.P., D.P.-C., B.Z., A.T., A.K.W., J.P., M.W.F.).ORCID 0000-0002-1468-6053
Jorge PlutzkyDepartment of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (R.Z., J.C., H.S.C., C.A., A.J., A.K.P., D.P.-C., B.Z., A.T., A.K.W., J.P., M.W.F.).ORCID 0000-0002-7194-9876
Victor BarreraDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (V.B., P.B.).ORCID 0000-0003-0590-4634
Preetida BhetariyaDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA (V.B., P.B.).ORCID 0000-0002-1988-3830
Richard N MitchellDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (R.N.M.).
Zhongmin LiuDepartment of Cardiovascular Surgery, Shanghai East Hospital, Tongji University School of Medicine, China (R.Z., Z.L.).
Mark W FeinbergDepartment of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (R.Z., J.C., H.S.C., C.A., A.J., A.K.P., D.P.-C., B.Z., A.T., A.K.W., J.P., M.W.F.).ORCID 0000-0001-9523-3859
Brigham and Women's Hospital · USHarvard University · USShanghai East Hospital · CN
Funding
STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JONATHAN C KAGAN · 1986 to 2026
$32.4MMiR-181b, endothelial cells, and vascular inflammationR01HL115141 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI FEINBERG, MARK W · 2012 to 2024
$6.8MmiR-615, AKT/eNOS signaling, and angiogenesisR01HL148207 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI FEINBERG, MARK W · 2020 to 2023
$2.6MLncRNA SNHG12, vascular senescence, and atherosclerosisR01HL148355 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI FEINBERG, MARK W · 2020 to 2023
$2.5MKLF10, CD4+ T cells, and transplant arteriopathyR01HL134849 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI FEINBERG, MARK W · 2017 to 2020
$1.7MLncRNA MAARS, macrophage apoptosis, and atherosclerosisR01HL153356 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI FEINBERG, MARK W · 2020 to 2023
$1.7MNHLBI NIH HHS R01 HL115141NHLBI NIH HHS R01 HL134849NHLBI NIH HHS R01 HL148207NHLBI NIH HHS R01 HL148355NHLBI NIH HHS R01 HL153356NIDDK NIH HHS P30 DK034854
Abstract
backgroundPerivascular fibrosis, characterized by increased amount of connective tissue around vessels, is a hallmark for vascular disease. Ang II (angiotensin II) contributes to vascular disease and end-organ damage via promoting T-cell activation. Despite recent data suggesting the role of T cells in the progression of perivascular fibrosis, the underlying mechanisms are poorly understood.
methodsTF (transcription factor) profiling was performed in peripheral blood mononuclear cells of hypertensive patients. CD4-targeted KLF10 (Kruppel like factor 10)-deficient (
resultsTF profiling identified increased
conclusionsCD4+ T cell deficiency of
Indexed as
CD4-Positive T-LymphocytesHypertensionAngiotensin IIAnimalsEarly Growth Response Transcription FactorsFibrosisHumansInterleukin-9Kruppel-Like Transcription FactorsLeukocytes, MononuclearMiceMice, Inbred C57BLMice, KnockoutRNAAngiotensin IIEarly Growth Response Transcription FactorsInterleukin-9KLF10 protein, humanKLF10 protein, mouseKruppel-Like Transcription FactorsRNAangiotensin II (Ang II)interleukins (IL)-9Kruppel like factor 10 (KLF10)perivascular fibrosisT cell
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