Evidence map›Paper›PMID 35440169›Full record

ArticleStroke2022

Impact of Previous Stroke on Clinical Outcome in Elderly Patients With Nonvalvular Atrial Fibrillation: ANAFIE Registry.

Takeshi Yoshimoto, Kazunori Toyoda, Masafumi Ihara, Hiroshi Inoue, Takeshi Yamashita, Shinya Suzuki, Masaharu Akao, Hirotsugu Atarashi, Takanori Ikeda, Ken Okumura and 11 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 15 institutions in 2 countries.

Takeshi YoshimotoDepartment of Neurology (T. Yoshimoto, M.I.), National Cerebral and Cardiovascular Center, Suita, Japan.ORCID 0000-0003-3178-8171
Kazunori ToyodaDepartment of Cerebrovascular Medicine (K.T., T. Yamaguchi), National Cerebral and Cardiovascular Center, Suita, Japan.ORCID 0000-0002-8346-9845
Masafumi IharaDepartment of Neurology (T. Yoshimoto, M.I.), National Cerebral and Cardiovascular Center, Suita, Japan.ORCID 0000-0002-7102-4048
Hiroshi InoueSaiseikai Toyama Hospital, Toyama, Japan (H.I.).ORCID 0000-0002-0775-8936
Takeshi YamashitaThe Cardiovascular Institute, Tokyo, Japan (T. Yamashita, S.S.).ORCID 0000-0002-2544-8464
Shinya SuzukiThe Cardiovascular Institute, Tokyo, Japan (T. Yamashita, S.S.).ORCID 0000-0002-4769-5925
Masaharu AkaoDepartment of Cardiology, NHO Kyoto Medical Center, Kyoto, Japan (M.A.).ORCID 0000-0002-2348-7646
Hirotsugu AtarashiAOI Hachioji Hospital, Tokyo, Japan (H.A.).ORCID 0000-0001-8181-9154
Takanori IkedaDepartment of Cardiovascular Medicine, Toho University Faculty of Medicine, Tokyo, Japan (T.I.).ORCID 0000-0003-0096-438X
Ken OkumuraDivision of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Japan (K.O.).ORCID 0000-0002-3202-7203
Yukihiro KoretsuneNHO Osaka National Hospital, Japan (Y.K.).ORCID 0000-0003-1650-8362
Wataru ShimizuDivision of Cardiology, Nippon Medical School Department of Medicine, Tokyo, Japan (W.S.).ORCID 0000-0001-9941-8973
Hiroyuki TsutsuiDepartment of Cardiovascular Medicine, Kyushu University Graduate School of Medical Science, Fukuoka, Japan (H.T.).
Atsushi HirayamaOsaka Police Hospital, Japan (A.H.).
Masahiro YasakaDepartment of Cerebrovascular Medicine and Neurology, Cerebrovascular Center, NHO Kyushu Medical Center, Fukuoka, Japan (M.Y.).ORCID 0000-0002-1163-8355
Hirofumi MaruyamaORCID 0000-0001-7613-8717
Satoshi TeramukaiDepartment of Biostatistics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan (S.T.).ORCID 0000-0003-2184-0597
Tetsuya KimuraPrimary Medical Science Department, Daiichi Sankyo, Tokyo, Japan (T.K., Y.M.).
Yoshiyuki MorishimaPrimary Medical Science Department, Daiichi Sankyo, Tokyo, Japan (T.K., Y.M.).ORCID 0000-0002-5062-1134
Atsushi TakitaData Intelligence Department, Daiichi Sankyo Co., Ltd., Tokyo, Japan (A.T.).
Takenori YamaguchiDepartment of Cerebrovascular Medicine (K.T., T. Yamaguchi), National Cerebral and Cardiovascular Center, Suita, Japan.ORCID 0000-0002-8611-4994
National Cerebral and Cardiovascular Center · JPDaiichi-Sankyo (Japan) · JPCardiovascular Institute Hospital · JPKyoto Medical Center · JPKyoto Prefectural University of Medicine · JPKyushu University · JPMaruyama Memorial General Hospital · JPNational Kyushu Medical Center · JPNippon Medical School Hospital · JPOsaka National Hospital · JPOsaka Police Hospital · JPSaiseikai Kumamoto Hospital · JPToho University · JPTokai University Hachioji Hospital · JPToyama University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe determined the long-term event incidence among elderly patients with nonvalvular atrial fibrillation in terms of history of stroke/transient ischemic attack (TIA) and oral anticoagulation.

methodsPatients aged ≥75 years with documented nonvalvular atrial fibrillation enrolled in the prospective, multicenter, observational All Nippon Atrial Fibrillation in the Elderly Registry between October 2016 and January 2018 were divided into 2 groups according to history of stroke/TIA. The primary end point was the occurrence of stroke/systemic embolism within 2 years, and secondary end points were major bleeding and all-cause death within 2 years. Cox models were used to determine whether there was a difference in the hazard of each end point in patients with/without history of stroke/TIA, and in ischemic stroke/TIA survivors taking direct oral anticoagulants versus those taking warfarin.

resultsOf 32 275 evaluable patients (13 793 women [42.7%]; median age, 81.0 years), 7304 (22.6%) had a history of stroke/TIA. The patients with previous stroke/TIA were more likely to be male and older and had higher hazard rates of stroke/systemic embolism (adjusted hazard ratio, 2.25 [95% CI, 1.97-2.58]), major bleeding (1.25, 1.05-1.49), and all-cause death (1.13, 1.02-1.24) than the other groups. Of 6446 patients with prior ischemic stroke/TIA, 4393 (68.2%) were taking direct oral anticoagulants and 1668 (25.9%) were taking warfarin at enrollment. The risk of stroke/systemic embolism was comparable between these 2 groups (adjusted hazard ratio, 0.90 [95% CI, 0.71-1.14]), while the risk of major bleeding (0.67, 0.48-0.94), intracranial hemorrhage (0.57, 0.39-0.85), and cardiovascular death (0.71, 0.51-0.99) was lower among those taking direct oral anticoagulants.

conclusionsPatients aged ≥75 years with nonvalvular atrial fibrillation and previous stroke/TIA more commonly had subsequent ischemic and hemorrhagic events than those without previous stroke/TIA. Among patients with previous ischemic stroke/TIA, the risk of hemorrhagic events was lower in patients taking direct oral anticoagulants compared with warfarin. REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique Identifier: UMIN000024006.

Indexed as

Atrial FibrillationEmbolismIschemic Attack, TransientIschemic StrokeStrokeAdministration, OralAgedAged, 80 and overAnticoagulantsFemaleHemorrhageHumansMaleProspective StudiesRegistriesTreatment OutcomeAnticoagulantsWarfarinatrial fibrillationcardioembolismdirect oral anticoagulantselderlyintracranial hemorrhagestroke

Identifiers

PMID35440169
PMCPMC9311295
OpenAlexW4224230577

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.