Evidence map›Paper›PMID 35439529›Full record

ArticleJournal of immunological methods2022

Detection of SARS-CoV-2 peptide-specific antibodies in Syrian hamster serum by ELISA.

Huy Quang Quach, Inna G Ovsyannikova, Gregory A Poland, Richard B Kennedy

Open access · greenAbstract read
In one paragraph

Article in Journal of immunological methods, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Vaccines · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Huy Quang QuachMayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, United States.
Inna G OvsyannikovaMayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, United States.
Gregory A PolandMayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, United States.
Richard B KennedyMayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, United States. Electronic address: kennedy.rick@mayo.edu.
Mayo Clinic in Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Golden Syrian hamsters are increasingly used as a permissive animal model for SARS-CoV-2 virus studies, but the lack of immunological assays and other immunological reagents for hamsters limits its full potential. Herein, we developed an ELISA method to detect antibodies specific to peptides and proteins derived from SARS-CoV-2 virus in immunized golden Syrian hamsters. Under optimized conditions, this assay quantitates antibodies specific for individual viral peptides, peptide pools, and proteins. Hence, this ELISA method allows investigators to quantitatively assess humoral immune responses at the peptide and protein levels and has potential application in the development of peptide-based vaccines to be tested in hamsters.

Indexed as

COVID-19SARS-CoV-2AnimalsAntibodies, ViralCricetinaeDisease Models, AnimalEnzyme-Linked Immunosorbent AssayMesocricetusPeptidesAntibodies, ViralPeptidesCOVID-19 vaccineELISAGolden Syrian hamstersPeptide-based vaccineSARS-CoV-2

Identifiers

PMID35439529
PMCPMC9013014
OpenAlexW4224000977

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.