Evidence map›Paper›PMID 35439525›Full record

ArticleJournal of lipid research2022

Sulfatide with ceramide composed of phytosphingosine (t18:0) and 2-hydroxy FAs in renal intercalated cells.

Keiko Nakashima, Yukie Hirahara, Taro Koike, Susumu Tanaka, Keizo Gamo, Souichi Oe, Shinichi Hayashi, Ryohei Seki-Omura, Yousuke Nakano, Chisato Ohe and 6 more

Open access · goldAbstract read
In one paragraph

Article in Journal of lipid research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Functions of Sulfatide in the Nervous, Immune, and Urinary Systems.Advances in experimental medicine and biology · 2026
    Review
  3. A lipid atlas of the human kidney.Science advances · 2025
    Article
  4. Article
  5. Sphingolipid signaling in kidney diseases.American journal of physiology. Renal physiology · 2025
    Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Keiko NakashimaDepartment of Anatomy.
Yukie HiraharaDepartment of Anatomy. Electronic address: hirahary@hirakata.kmu.ac.jp.
Taro KoikeDepartment of Anatomy.
Susumu TanakaDepartment of Anatomy.
Keizo GamoDepartment of Anatomy.
Souichi OeDepartment of Anatomy.
Shinichi HayashiDepartment of Anatomy.
Ryohei Seki-OmuraDepartment of Anatomy.
Yousuke NakanoDepartment of Anatomy.
Chisato OheDepartment of Pathology.
Takashi YoshidaDepartment of Urology and Andrology, Kansai Medical University, Hirakata, Osaka, Japan.
Yosky KataokaLaboratory for Cellular Function Imaging, RIKEN Center for Biosystems Dynamics Research; Multi-Modal Microstructure Analysis Unit, RIKEN-JEOL Collaboration Center, Kobe, Hyogo, Japan.
Masayuki TsudaDivision of Laboratory Animal Science Research Center.
Tatsuyuki YamashitaDepartment of Biochemistry, Kochi University Medical School, Nangoku, Kochi, Japan.
Koichi HonkeDepartment of Biochemistry, Kochi University Medical School, Nangoku, Kochi, Japan.
Masaaki KitadaDepartment of Anatomy.
Kōchi University · JPJEOL (Japan) · JPKansai Medical University · JPMunicipal Hirakata City Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diverse molecular species of sulfatide with differences in FA lengths, unsaturation degrees, and hydroxylation statuses are expressed in the kidneys. However, the physiological functions of specific sulfatide species in the kidneys are unclear. Here, we evaluated the distribution of specific sulfatide species in the kidneys and their physiological functions. Electron microscopic analysis of kidneys of Cst-deficient mice lacking sulfatide showed vacuolar accumulation in the cytoplasm of intercalated cells in the collecting duct, whereas the proximal and distal tubules were unchanged. Immunohistochemical analysis revealed that vacuolar H

Indexed as

SulfoglycosphingolipidsVacuolar Proton-Translocating ATPasesAnimalsCeramidesKidneyMiceSphingosineCeramidesphytosphingosineSphingosineSulfoglycosphingolipidsVacuolar Proton-Translocating ATPaseselectron microscopic analysisimaging MSintercalated cellkidneysulfatide

Identifiers

PMID35439525
PMCPMC9157219
OpenAlexW4223956164

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.