Evidence map›Paper›PMID 35438701›Full record

ArticleNanoscale2022

Size-tuneable and immunocompatible polymer nanocarriers for drug delivery in pancreatic cancer.

Andrea Bistrović Popov, Francesca Melle, Emily Linnane, Cristina González-López, Ishtiaq Ahmed, Badri Parshad, Christoph O Franck, Hassan Rahmoune, Frances M Richards, Daniel Muñoz-Espín and 3 more

Abstract read
In one paragraph

Article in Nanoscale, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Andrea Bistrović PopovBioNano Engineering Lab, Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, UK. lf389@cam.ac.uk.
Francesca MelleThe Adsorption & Advanced Materials Laboratory (A2ML), Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, UK.
Emily LinnaneThe Adsorption & Advanced Materials Laboratory (A2ML), Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, UK.
Cristina González-LópezBioNano Engineering Lab, Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, UK. lf389@cam.ac.uk.
Ishtiaq AhmedBioNano Engineering Lab, Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, UK. lf389@cam.ac.uk.
Badri ParshadBioNano Engineering Lab, Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, UK. lf389@cam.ac.uk.
Christoph O FranckBioNano Engineering Lab, Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, UK. lf389@cam.ac.uk.
Hassan RahmouneDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, UK.
Frances M RichardsCancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge CB2 0RE, UK.ORCID http://orcid.org/0000-0001-7947-7853
Daniel Muñoz-EspínCRUK Cambridge Centre Early Detection Program, Department of Oncology, Hutchison/MRC Research Centre, University of Cambridge, Cambridge CB2 0RE, UK.
Duncan I JodrellCancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge CB2 0RE, UK.
David Fairen-JimenezThe Adsorption & Advanced Materials Laboratory (A2ML), Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, UK.ORCID http://orcid.org/0000-0002-5013-1194
Ljiljana FrukBioNano Engineering Lab, Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, UK. lf389@cam.ac.uk.

Funding

Cancer Research UK 26989Cancer Research UK 27338Cancer Research UK 29760Medical Research Council MR/R000530/1
6 · The paper itself

Abstract

Nanocarriers have emerged as one of the most promising approaches for drug delivery. Although several nanomaterials have been approved for clinical use, the translation from lab to clinic remains challenging. However, by implementing rational design strategies and using relevant models for their validation, these challenges are being addressed. This work describes the design of novel immunocompatible polymer nanocarriers made of melanin-mimetic polydopamine and Pluronic F127 units. The nanocarrier preparation was conducted under mild conditions, using a highly reproducible method that was tuned to provide a range of particle sizes (<100 nm) without changing the composition of the carrier. A set of

Indexed as

NanoparticlesPancreatic NeoplasmsDrug CarriersDrug Delivery SystemsHistocompatibilityHumansPolymersTumor MicroenvironmentDrug CarriersPolymers

Identifiers

PMID35438701
PMCPMC9070568

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.