ArticleeLife2022
Neural excursions from manifold structure explain patterns of learning during human sensorimotor adaptation.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Article
- Developmental tuning of functional manifold dimensionality across the human brain.bioRxiv : the preprint server for biology · 2026Article
- The retrieval of previously learned motor memories is facilitated by the reinstatement of default mode network manifold structures.PLoS biology · 2026Article
- Transfer of motor learning is associated with patterns of activity in the default mode network.PLoS biology · 2025Article
- Hippocampal-entorhinal cognitive maps and cortical motor system represent action plans and their outcomes.Nature communications · 2025Article
- Visual Statistical Learning Alters Low-Dimensional Cortical Architecture.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Complexity in speech and music listening via neural manifold flows.Network neuroscience (Cambridge, Mass.) · 2025Article
- From gradients to cognition: linking cortical manifolds to brain flexibility and disorder.Frontiers in cognition · 2025Review
- Distinct patterns of connectivity with the motor cortex reflect different components of sensorimotor learning.PLoS biology · 2024Article
- Changes in cortical manifold structure following stroke and its relation to behavioral recovery in the male macaque.Nature communications · 2024Article
- Article
- Distinct manifold encoding of navigational information in the subiculum and hippocampus.Science advances · 2024Article
- The engagement of the cerebellum and basal ganglia enhances expertise in a sensorimotor adaptation task.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Cerebellar Degeneration Impairs Strategy Discovery but Not Strategy Recall.Cerebellum (London, England) · 2023Article
- Distinct patterns of cortical manifold expansion and contraction underlie human sensorimotor adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Neural excursions from manifold structure explain patterns of learning during human sensorimotor adaptation.eLife · 2022Article
Corrections and comments
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Authors and funding
6 authors.
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Abstract
Humans vary greatly in their motor learning abilities, yet little is known about the neural mechanisms that underlie this variability. Recent neuroimaging and electrophysiological studies demonstrate that large-scale neural dynamics inhabit a low-dimensional subspace or manifold, and that learning is constrained by this intrinsic manifold architecture. Here, we asked, using functional MRI, whether subject-level differences in neural excursion from manifold structure can explain differences in learning across participants. We had subjects perform a sensorimotor adaptation task in the MRI scanner on 2 consecutive days, allowing us to assess their learning performance across days, as well as continuously measure brain activity. We find that the overall neural excursion from manifold activity in both cognitive and sensorimotor brain networks is associated with differences in subjects' patterns of learning and relearning across days. These findings suggest that off-manifold activity provides an index of the relative engagement of different neural systems during learning, and that subject differences in patterns of learning and relearning are related to reconfiguration processes occurring in cognitive and sensorimotor networks.
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