Evidence map›Paper›PMID 35438384›Full record

ReviewCurrent HIV/AIDS reports2022

Viral and Host Biomarkers of HIV Remission Post Treatment Interruption.

Leila B Giron, Mohamed Abdel-Mohsen

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current HIV/AIDS reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Leila B GironThe Wistar Institute, Philadelphia, PA, USA. lgiron@wistar.org.ORCID 0000-0002-3898-5680
Mohamed Abdel-MohsenThe Wistar Institute, Philadelphia, PA, USA.

Funding

Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI DAVID S METZGER · 1999 to 2026
$78.6M
BEAT-HIV: Delaney Collaboratory to Cure HIV-1 Infection by Combination ImmunotherapyUM1AI164570 · NIAID · WISTAR INSTITUTE · PI Luis J Montaner, James L. Riley · 2021 to 2026
$34.7M
Role of Intestinal Barrier Integrity in Modulating the Host Glycome During COVID-19R01DK123733 · NIDDK · WISTAR INSTITUTE · PI ABDEL MOHSEN, MOHAMED, KESHAVARZIAN, ALI · 2020 to 2024
$4.5M
Host Glycomic Modulation of HIV-associated Neuro-inflammation During Viral SuppressionR01NS117458 · NINDS · WISTAR INSTITUTE · PI ABDEL MOHSEN, MOHAMED, NDHLOVU, LISHOMWA C · 2020 to 2023
$3.4M
Targeting Siglec-9/Sialoglycan Interactions to Enhance NK Functions During HIV InfectionR01AI165079 · NIAID · WISTAR INSTITUTE · PI ABDEL MOHSEN, MOHAMED, XIAO, HAN · 2021 to 2025
$3.1M
Sialic Acid Modulation of HIV-associated Chronic InflammagingR01AG062383 · NIA · WISTAR INSTITUTE · PI ABDEL MOHSEN, MOHAMED · 2019 to 2023
$3.0M
Microbiota-Mediated Bidirectional Interactions Between Alcohol Misuse and Post-COVID-19 SyndromeR01AA029859 · NIAAA · RUSH UNIVERSITY MEDICAL CENTER · PI ABDEL MOHSEN, MOHAMED, KESHAVARZIAN, ALI · 2021 to 2023
$632k
Single-cell Analysis of Glycomic and Proteomic Features of the HIV ReservoirR21AI170166 · NIAID · WISTAR INSTITUTE · PI ABDEL MOHSEN, MOHAMED, ROAN, NADIA R · 2022 to 2023
$530k
Exploring Cell-free Glycomic Interactions in HIV-associated Neurological DisordersR21NS106970 · NINDS · WISTAR INSTITUTE · PI ABDEL MOHSEN, MOHAMED, NDHLOVU, LISHOMWA C · 2017 to 2018
$507k
Role of Host Glycosylation in the Galectin-9-Mediated Reversal of HIV LatencyR21AI129636 · NIAID · WISTAR INSTITUTE · PI ABDEL MOHSEN, MOHAMED · 2017 to 2018
$496k
Host Glycomic Determinants of HIV Persistence in vivoR21AI143385 · NIAID · WISTAR INSTITUTE · PI ABDEL MOHSEN, MOHAMED · 2019 to 2020
$491k
NIAID NIH HHS R01 AI165079NIAID NIH HHS R21 AI129636NIAID NIH HHS R21 AI143385NIAID NIH HHS UM1 AI164570NIA NIH HHS R01 AG062383NIDDK NIH HHS R01 DK123733NIH HHS P30 AI 045008NIH HHS R01AG062383NIH HHS R01AI165079NIH HHS R01DK123733NIH HHS R01NS117458NINDS NIH HHS R01 NS117458NINDS NIH HHS R21 NS106970
6 · The paper itself

Abstract

purpose of reviewHIV rebound/remission after antiretroviral therapy (ART) interruption is likely influenced by (a) the size of the inducible replication-competent HIV reservoir and (b) factors in the host environment that influence immunological pressures on this reservoir. Identifying viral and/or host biomarkers of HIV rebound after ART cessation may improve the safety of treatment interruptions and our understanding of how the viral-host interplay results in post-treatment control. Here we review the predictive and functional significance of recently suggested viral and host biomarkers of time to viral rebound and post-treatment control following ART interruption. RECENT

findingsThere are currently no validated viral or host biomarkers of viral rebound; however, several biomarkers have been recently suggested. A combination of viral and host factors will likely be needed to predict viral rebound and to better understand the mechanisms contributing to post-treatment control of HIV, critical steps to developing a cure for HIV infection.

Indexed as

Anti-Retroviral AgentsHIV InfectionsBiomarkersHumansViral LoadAnti-Retroviral AgentsBiomarkersBiomarkersHIVPost-treatment controllersViral rebound

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.