ArticleAMB Express2022
Bioprospecting endophytic fungi for bioactive metabolites and use of irradiation to improve their bioactivities.
Article in AMB Express, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Untapped microbial factories for next-generation therapeutics: Endophytic fungi of medicinal plants.Microbial cell factories · 2026Review
- Amesia nigricolor, a novel endophyte of Encephalartos bubalinus, exhibiting a robust taxol biosynthetic stability: chemical characterization and biological activities.Microbial cell factories · 2025Article
- Bioprospecting Endophytic Fungi of Forest Plants for Bioactive Metabolites with Antibacterial, Antifungal, and Antioxidant Potentials.Molecules (Basel, Switzerland) · 2024Article
- Article
- Bioprospecting endophytic fungi for bioactive metabolites with seed germination promoting potentials.BMC microbiology · 2024Article
- Article
- Myco-fabricated ZnO nanoparticles ameliorate neurotoxicity in mice model of Alzheimer's disease via acetylcholinesterase inhibition and oxidative stress reduction.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023Article
- Bifunctional role of some biogenic nanoparticles in controlling wilt disease and promoting growth of common bean.AMB Express · 2023Article
- Improvement in the Phytochemical Content and Biological Properties ofPlants (Basel, Switzerland) · 2023Article
- Gamma irradiation mediated production improvement of some myco-fabricated nanoparticles and exploring their wound healing, anti-inflammatory and acetylcholinesterase inhibitory potentials.Scientific reports · 2023Article
- Bioprospecting endophytic fungi for antifeedants and larvicides and their enhancement by gamma irradiation.AMB Express · 2022Article
- Improving carboxymethyl cellulose edible coating using ZnO nanoparticles from irradiated Alternaria tenuissima.AMB Express · 2022Article
- A new endophyte Monascus ruber SRZ112 as an efficient production platform of natural pigments using agro-industrial wastes.Scientific reports · 2022Article
- Harnessing endophytic fungi for biosynthesis of selenium nanoparticles and exploring their bioactivities.AMB Express · 2022Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The search for new bioactive compounds with innovative modes of action and chemistry are desperately needed to tackle the increased emergence of drug-resistant microbes. With this view, this paper was conducted for the isolation, identification, and biological evaluation of fungal endophytes of eleven different plant species. A total of 69 endophytic strains were isolated and tested for the presence of bioactive metabolites with antifungal, antibacterial, anticancer, and antioxidant properties in their extracts. Upon screening, two promising strains were found to have all the before-mentioned activities. These strains were Aspergillus sydowii isolated from the bark of Ricinus communis and Aspergillus flavus isolated from the twigs of Psidium guajava. Major compounds present in extracts of the two strains were identified by GC-Mass analyses. Several well-known bioactive compounds as well as unreported ones were identified in the fungal extracts of the two strains. Furthermore, gamma irradiation (at 1000 Gy) of the fungal cultures resulted in improved bioactivities of extracts from the two strains. These findings recommend the two fungal strains as sources of antimicrobial, anticancer, and antioxidant compounds which may aid in the development of novel drugs. The presented research also explains the high-value of fungal endophytes as untapped sources of bioactive metabolites.
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