Evidence map›Paper›PMID 35438261›Full record

ArticleESC heart failure2022

Non-invasive evaluation of new-onset atrial fibrillation after cardiac surgery: a protocol for the BigMap study.

Constantin Mork, Simon Adrian Amacher, Brigitta Gahl, Luca Koechlin, Jules Miazza, Thibault Schaeffer, Lena Schmuelling, Jens Bremerich, Denis Berdajs, Nadine Cueni and 13 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 2 institutions in 2 countries.

Constantin MorkDepartment of Cardiac Surgery, University Hospital Basel, Spitalstrasse 21, Basel, 4031, Switzerland.
Simon Adrian AmacherIntensive Care Unit, University Hospital Basel, Basel, Switzerland.ORCID 0000-0001-6530-1240
Brigitta GahlDepartment of Cardiac Surgery, University Hospital Basel, Spitalstrasse 21, Basel, 4031, Switzerland.
Luca KoechlinDepartment of Cardiac Surgery, University Hospital Basel, Spitalstrasse 21, Basel, 4031, Switzerland.
Jules MiazzaDepartment of Cardiac Surgery, University Hospital Basel, Spitalstrasse 21, Basel, 4031, Switzerland.
Thibault SchaefferDepartment of Cardiac Surgery, University Hospital Basel, Spitalstrasse 21, Basel, 4031, Switzerland.
Lena SchmuellingDepartment of Radiology, University Hospital Basel, Basel, Switzerland.
Jens BremerichDepartment of Radiology, University Hospital Basel, Basel, Switzerland.
Denis BerdajsDepartment of Cardiac Surgery, University Hospital Basel, Spitalstrasse 21, Basel, 4031, Switzerland.
Nadine CueniIntensive Care Unit, University Hospital Basel, Basel, Switzerland.
Michael KühneCardiovascular Research Institute (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Christian MuellerCardiovascular Research Institute (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Stefan OsswaldCardiovascular Research Institute (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Oliver ReuthebuchDepartment of Cardiac Surgery, University Hospital Basel, Spitalstrasse 21, Basel, 4031, Switzerland.
Ulrich SchurrDepartment of Cardiac Surgery, University Hospital Basel, Spitalstrasse 21, Basel, 4031, Switzerland.
Christian SticherlingCardiovascular Research Institute (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Andrea Kopp LugliMedical Faculty of the University of Basel, Basel, Switzerland.
Stephan MarschIntensive Care Unit, University Hospital Basel, Basel, Switzerland.
Hans ParggerIntensive Care Unit, University Hospital Basel, Basel, Switzerland.
Martin SiegemundIntensive Care Unit, University Hospital Basel, Basel, Switzerland.
Friedrich EcksteinDepartment of Cardiac Surgery, University Hospital Basel, Spitalstrasse 21, Basel, 4031, Switzerland.
Alexa HollingerIntensive Care Unit, University Hospital Basel, Basel, Switzerland.
David SanterDepartment of Cardiac Surgery, University Hospital Basel, Spitalstrasse 21, Basel, 4031, Switzerland.ORCID 0000-0003-4493-4326
University of Basel · CHUniversity Hospital of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsNew-onset atrial fibrillation (NOAF) is the most common complication after cardiac surgery, occurring in 25-50% of patients. It is associated with post-operative stroke, increased mortality, prolonged hospital length of stay, and higher treatment costs. Previous small observational studies have identified the left atrium as a source of the electrical rotors and foci maintaining NOAF, but confirmation by a large prospective clinical study is still missing. The aim of the proposed study is to investigate whether the source of NOAF lies in the left atrium. The correct identification of NOAF-maintaining structures in cardiac surgical patients might offer potential therapeutic targets for prophylactic perioperative ablation strategies. METHODS AND

resultsThis is a prospective single-centre observational study of patients developing NOAF after cardiac surgery. The primary outcome is the description of NOAF-maintaining structures within the atria. Key secondary outcomes include overall mortality, intensive care unit length of stay, hospital-ventilator-free days, and proportion of persistent NOAF. In NOAF patients, the non-invasive electrophysiological mapping will be conducted using a 252-electrode electrocardiogram vest. After mapping, a low-dose computed tomography scan of the chest will be performed to integrate the electrophysiological mapping results into a 3D picture of the heart. The study will include approximately 570 patients, of whom 30% (n = 170) are expected to develop NOAF. Sample size calculation revealed that 157 NOAF patients are necessary to assess the primary outcome. Patients will be tracked for a total of 5 years.

conclusionsThis is the largest prospective study to date describing the electrophysiological mechanisms of NOAF using non-invasive mapping.

Indexed as

Atrial FibrillationCardiac Surgical ProceduresElectrocardiographyHumansObservational Studies as TopicProspective StudiesRisk FactorsCardiac surgeryCardiac surgical critical careNew-onset atrial fibrillationNon-invasive cardiac mapping

Identifiers

PMID35438261
PMCPMC9288739
OpenAlexW4224284283

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.