Evidence map›Paper›PMID 35438201›Full record

ArticleAnnals of neurology2022

Ictal Electroencephalographic Characteristics of Nodding Syndrome: A Comparative Case-Series from South Sudan, Tanzania, and Uganda.

Rajarshi Mazumder, David Kitara Lagoro, Hiroki Nariai, Alberto Danieli, Dawn Eliashiv, Jerome Engel, Bernardo Dalla Bernardina, Josua Kegele, Holger Lerche, James Sejvar and 6 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

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  2. Review
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 7 countries.

Rajarshi MazumderDavid Geffen School of Medicine, Department of Neurology, University of California, Los Angeles, CA.ORCID 0000-0002-0489-5089
David Kitara LagoroFaculty of Medicine, Department of surgery, Gulu University, Gulu, Uganda.
Hiroki NariaiDivision of Pediatric Neurology, Department of Pediatrics, UCLA Mattel Children's Hospital, David Geffen School of Medicine, University of California, Los Angeles, CA.
Alberto DanieliEpilepsy and Clinical Neurophysiology Unit, Scientific Institute IRCCS E. Medea, Conegliano (TV), Italy.
Dawn EliashivDavid Geffen School of Medicine, Department of Neurology, University of California, Los Angeles, CA.
Jerome EngelDavid Geffen School of Medicine, Department of Neurology, University of California, Los Angeles, CA.ORCID 0000-0001-6324-5716
Bernardo Dalla BernardinaChild Neuropsychiatry, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy.
Josua KegeleDepartment of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Holger LercheDepartment of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
James SejvarDivision of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA.
William MatujaDepartment of Neurology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Erich SchmutzhardDepartment of Neurology, Medical University Innsbruck, Innsbruck, Austria.
Paolo BonanniEpilepsy and Clinical Neurophysiology Unit, Scientific Institute IRCCS E. Medea, Conegliano (TV), Italy.
Gianni De PoloScientific Institute IRCCS E. Medea, Conegliano (TV), Italy.
Thomas WagnerCenter for Childhood and Adolescent Medicine, Heidelberg University Hospital, Heidelberg, Germany.
Andrea Sylvia WinklerDepartment of Neurology, Center for Global Health, School of Medicine, Technical University of Munich, Munich, Germany.ORCID 0000-0003-3131-6983
University of California, Los Angeles · USIRCCS Eugenio Medea · ITHertie Institute for Clinical Brain Research · DECenters for Disease Control and Prevention · USGulu University · UGHeidelberg University · DEInnsbruck Medical University · ATMuhimbili University of Health and Allied Sciences · TZUniversity of Oslo · NOUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nodding syndrome (NS) is a poorly understood form of childhood-onset epilepsy that is characterized by the pathognomonic ictal phenomenon of repetitive vertical head drops. To evaluate the underlying ictal neurophysiology, ictal EEG features were evaluated in nine participants with confirmed NS from South Sudan, Tanzania, and Uganda and ictal presence of high frequency gamma oscillations on scalp EEG were assessed. Ictal EEG during the head nodding episode predominantly showed generalized slow waves or sharp-and-slow wave complexes followed by electrodecrement. Augmentation of gamma activity (30-70 Hz) was seen during the head nodding episode in all the participants. We confirm that head nodding episodes in persons with NS from the three geographically distinct regions in sub-Saharan Africa share the common features of slow waves with electrodecrement and superimposed gamma activity. ANN NEUROL 2022;92:75-80.

Indexed as

Nodding SyndromeElectroencephalographyHumansSouth SudanTanzaniaUganda

Identifiers

PMID35438201
PMCPMC9544008
OpenAlexW4224217789

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.