ArticleJournal of the National Cancer Institute2022
Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study.
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Article in Journal of the National Cancer Institute, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
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18 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Risk factors of ovarian cancer: a systematic review and meta-analysis of Mendelian randomiation studies.Journal of public health (Oxford, England) · 2026Pooled it
- Early-life anthropometry and colorectal cancer risk in adulthood: Global Cancer Update Programme (CUP Global) systematic literature review and meta-analysis of prospective studies.International journal of cancer · 2025Pooled it
- Body mass index and lung cancer risk: Pooled analysis of 10 prospective cohort studies in Japan.Cancer science · 2024Pooled it
- Separating the effects of early and later life adiposity on colorectal cancer risk: a Mendelian randomization study.BMC medicine · 2023Pooled it
- The Tumor Multi-Omic Landscape of Endometrial Cancers Developed on a Background of Adiposity.Genes · 2026Article
- Adiposity and cancer: epidemiology, mechanisms and future perspectives.Nature metabolism · 2026Review
- Genetically determined body mass index is associated with diffuse large B-cell lymphoma in polygenic and Mendelian randomization analyses.International journal of cancer · 2026Article
- Pan-cancer analysis of the impact of fatty acids: a two-sample and multivariable Mendelian randomization study.Discover oncology · 2025Article
- Genetically proxied risk and protective factors for pancreatic cancer: a systematic review and meta-analysis of Mendelian randomization studies.Journal of gastrointestinal oncology · 2025Article
- Are associations of adulthood overweight and obesity with all-cause mortality, cardiovascular disease, and obesity-related cancer modified by comparative body weight at age 10 years in the UK Biobank study?International journal of obesity (2005) · 2025Article
- Body mass index at birth and early life and colorectal cancer: A two-sample Mendelian randomization analysis in European and East Asian genetic similarity populations.Pediatric obesity · 2025Article
- Smoking and alcohol by HPV status in head and neck cancer: a Mendelian randomization study.Nature communications · 2024Article
- Using Genetics to Investigate Relationships between Phenotypes: Application to Endometrial Cancer.Genes · 2024Review
- Time-varying and tissue-dependent effects of adiposity on leptin levels: A Mendelian randomization study.eLife · 2023Article
- Age at Menarche, age at Natural Menopause, and Risk of Lung and Colorectal Cancers: A Mendelian Randomization Study.Journal of the Endocrine Society · 2023Article
- Body mass index and the risk of abdominal hernia: a Mendelian randomization study.Hernia : the journal of hernias and abdominal wall surgery · 2023Article
- Causal relationship between gut microbiota and cancers: a two-sample Mendelian randomisation study.BMC medicine · 2023Article
- Early-life exposures and adulthood cancer risk: A life course perspective.Journal of the National Cancer Institute · 2023Article
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Authors and funding
36 authors.
Daniela MariosaInternational Agency for Research on Cancer (IARC/WHO), Genomic Epidemiology Branch, Lyon, France.ORCID 0000-0001-8181-1419
Karl Smith-ByrneInternational Agency for Research on Cancer (IARC/WHO), Genomic Epidemiology Branch, Lyon, France.ORCID 0000-0002-1932-7463
Tom G RichardsonMRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID 0000-0002-7918-2040
Pietro FerrariInternational Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, Lyon, France.ORCID 0000-0001-9358-7338
Marc J GunterInternational Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, Lyon, France.ORCID 0000-0001-5472-6761
Nikos PapadimitriouInternational Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, Lyon, France.
Neil MurphyInternational Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, Lyon, France.ORCID 0000-0003-3347-8249
Sofia ChristakoudiDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.ORCID 0000-0001-9219-4436
Konstantinos K TsilidisDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.ORCID 0000-0002-8452-8472
Elio RiboliDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.ORCID 0000-0001-6795-6080
David MullerDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.ORCID 0000-0002-2350-0417
Mark P PurdueDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Rayjean J HungProsserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.
Christopher I AmosInstitute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-8540-7023
Tracy A O'MaraDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Pilar AmianoMinistry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, San Sebastián, Spain.
Fabrizio PasanisiDipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy.
Miguel Rodriguez-BarrancoEscuela Andaluza de Salud Pública (EASP), Granada, Spain.ORCID 0000-0002-9972-9779
Vittorio KroghEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.ORCID 0000-0003-0122-8624
Anne TjønnelandDanish Cancer Society Research Center, Copenhagen, Denmark.
Jytte HalkjærDanish Cancer Society Research Center, Copenhagen, Denmark.
Aurora Perez-CornagoCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID 0000-0002-5652-356X
María-Dolores ChirlaqueCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Guri SkeieDepartment of Community Medicine, UiT, The Arctic University of Norway, Tromsø, Norway.ORCID 0000-0003-2476-4251
Charlotta RylanderDepartment of Community Medicine, UiT, The Arctic University of Norway, Tromsø, Norway.
Kristin Benjaminsen BorchDepartment of Community Medicine, UiT, The Arctic University of Norway, Tromsø, Norway.
Dagfinn AuneDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.ORCID 0000-0002-4533-1722
Alicia K HeathDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.ORCID 0000-0001-6517-1300
Heather A WardDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Matthias SchulzeDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.ORCID 0000-0002-0830-5277
Catalina BonetUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology- IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
Elisabete WeiderpassInternational Agency for Research on Cancer (IARC/WHO), Lyon, France.ORCID 0000-0003-2237-0128
George Davey SmithMRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Paul BrennanInternational Agency for Research on Cancer (IARC/WHO), Genomic Epidemiology Branch, Lyon, France.
Mattias JohanssonInternational Agency for Research on Cancer (IARC/WHO), Genomic Epidemiology Branch, Lyon, France.ORCID 0000-0002-3116-5081
Funding
Translating Molecular and Clinical Data to Population Lung Cancer Risk AssessmentU19CA203654 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Christopher I. Amos · 2017 to 2026
$23.7MTranslational Research Support CoreP30ES030285 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI Cheryl L. Walker · 2019 to 2026
$14.7MEpidemiologic StudiesU19CA148065 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI AHSAN, HABIBUL, BRUGGE, JOAN SIEFERT · 2010 to 2014
$10.6MOvarian cancer GWAS discovery, expansion and replication (N2 - Project #1)U19CA148112 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI SELLERS, THOMAS A · 2010 to 2014
$10.2MCOLLABORATIVE STUDY OF OVARIAN CANCER IN TWO RISK GROUPSR01CA058598 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI GOODMAN, MARC T · 1993 to 2012
$4.6MGenome-Wide Association Study of Endometrial CancerR01CA134958 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI DE VIVO, IMMACULATA · 2009 to 2010
$4.3MThe Mitochondrial Genome and Ovarian Cancer RiskR01CA149429 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI PHELAN, CATHERINE · 2010 to 2015
$3.1MCancer Research UK 29017Cancer Research UK 29019Cancer Research UK C18281/A29019Medical Research Council MC_UU_00011/1Medical Research Council MR/M012190/1NCI NIH HHS R01 CA058598NCI NIH HHS R01 CA134958NCI NIH HHS R01 CA149429NCI NIH HHS U19 CA148065NCI NIH HHS U19 CA148112NCI NIH HHS U19 CA203654Wellcome TrustWorld Health Organization 001
Abstract
It is unclear if body weight in early life affects cancer risk independently of adult body weight. To investigate this question for 6 obesity-related cancers, we performed univariable and multivariable analyses using 1) Mendelian randomization (MR) analysis and 2) longitudinal analyses in prospective cohorts. Both the MR and longitudinal analyses indicated that larger early life body size was associated with higher risk of endometrial (odds ratioMR = 1.61, 95% confidence interval = 1.23 to 2.11) and kidney (odds ratioMR = 1.40, 95% confidence interval = 1.09 to 1.80) cancer. These associations were attenuated after accounting for adult body size in both the MR and cohort analyses. Early life body mass index (BMI) was not consistently associated with the other investigated cancers. The lack of clear independent risk associations suggests that early life BMI influences endometrial and kidney cancer risk mainly through pathways that are common with adult BMI.
Indexed as
Mendelian Randomization AnalysisNeoplasmsAdultBody Mass IndexBody SizeCohort StudiesGenome-Wide Association StudyHumansObesityProspective Studies
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