ArticleeLife2022
Notch controls the cell cycle to define leader versus follower identities during collective cell migration.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- In vivo DNA damage protection during cell migration across confining embryonic tissue environments.Nature cell biology · 2026Article
- The long noncoding RNA Peanut (Gm11454) biases progenitors towards neurogenesis and rod photoreceptor differentiation during postnatal retinal development.Developmental biology · 2026Article
- Live imaging and multimodal profiling reveal transdifferentiation of a cochlear supporting cell subpopulation upon Notch inhibition.Science advances · 2026Article
- The long noncoding RNAbioRxiv : the preprint server for biology · 2025Article
- Rules of life at the interface of calcium signaling and mechanobiology.APL bioengineering · 2025Review
- Interphase cell morphology defines the mode, symmetry, and outcome of mitosis.Science (New York, N.Y.) · 2025Article
- Notch Is Required for Neural Progenitor Proliferation During Embryonic Eye Regrowth.International journal of molecular sciences · 2025Article
- Unveiling the impact of CD133 on cell cycle regulation in radio- and chemo-resistance of cancer stem cells.Frontiers in public health · 2025Review
- Multiscale computational model predicts how environmental changes and treatments affect microvascular remodeling in fibrotic disease.PNAS nexus · 2025Article
- Article
- Retinal primary cilia and their dysfunction in retinal neurodegenerative diseases: beyond ciliopathies.Molecular medicine (Cambridge, Mass.) · 2024Review
- Multiscale computational model predicts how environmental changes and drug treatments affect microvascular remodeling in fibrotic disease.bioRxiv : the preprint server for biology · 2024Article
- Mutations in cdon and boc affect trunk neural crest cell migration and slow-twitch muscle development in zebrafish.Development (Cambridge, England) · 2023Article
- Quantitative videomicroscopy reveals latent control of cell-pair rotations in vivo.Development (Cambridge, England) · 2023Article
- Article
- Who's really in charge: Diverse follower cell behaviors in collective cell migration.Current opinion in cell biology · 2023Review
- Increased collective migration correlates with germline stem cell competition in a basal chordate.PloS one · 2023Article
- Trunk Neural Crest Migratory Position and Asymmetric Division Predict Terminal Differentiation.Frontiers in cell and developmental biology · 2022Article
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 3 countries.
Funding
Abstract
Coordination of cell proliferation and migration is fundamental for life, and its dysregulation has catastrophic consequences, such as cancer. How cell cycle progression affects migration, and vice versa, remains largely unknown. We address these questions by combining in silico modelling and in vivo experimentation in the zebrafish trunk neural crest (TNC). TNC migrate collectively, forming chains with a leader cell directing the movement of trailing followers. We show that the acquisition of migratory identity is autonomously controlled by Notch signalling in TNC. High Notch activity defines leaders, while low Notch determines followers. Moreover, cell cycle progression is required for TNC migration and is regulated by Notch. Cells with low Notch activity stay longer in G
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.