Evidence map›Paper›PMID 35437687›Full record

Trial reportJournal of neuro-oncology2022

Managing cancer and living meaningfully (CALM) in adults with malignant glioma: a proof-of-concept phase IIa trial.

Ashlee R Loughan, Kelcie D Willis, Sarah Ellen Braun, Gary Rodin, Autumn Lanoye, Alexandria E Davies, Dace Svikis, Suzanne Mazzeo, Mark Malkin, Leroy Thacker

Registry-linked trialOpen access · greenAbstract readClinical Trial, Phase II
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of neuro-oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04646213 (Managing Cancer and Living Meaningfully), which is not on this map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04646213 nacompletednot on this map

Managing Cancer and Living Meaningfully (CALM) in Primary Brain Tumor Patients

TypeinterventionalSponsorVirginia Commonwealth UniversityRan2020 to 2022Enrolled14ConditionsMood, Cancer BrainArmsManaging Cancer and Living Meaningfully (CALM) Therapy
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Neuro-oncology practice · 2025
    Article
  8. Article
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  10. Article
  11. Article
  12. Article
  13. Depression and anxiety in glioma patients.Neuro-oncology practice · 2023
    Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Ashlee R LoughanDepartment of Neurology, School of Medicine, Virginia Commonwealth University, 1201 East Marshall St, Richmond, VA, 23298-0037, USA. ashlee.loughan@vcuhealth.org.ORCID http://orcid.org/0000-0003-1231-2469
Kelcie D WillisMassey Cancer Center, Richmond, VA, USA.
Sarah Ellen BraunDepartment of Neurology, School of Medicine, Virginia Commonwealth University, 1201 East Marshall St, Richmond, VA, 23298-0037, USA.
Gary RodinPrincess Margaret Cancer Center, Toronto, Canada.
Autumn LanoyeMassey Cancer Center, Richmond, VA, USA.
Alexandria E DaviesDepartment of Psychology, Virginia Commonwealth University, Richmond, VA, USA.
Dace SvikisDepartment of Psychology, Virginia Commonwealth University, Richmond, VA, USA.
Suzanne MazzeoDepartment of Psychology, Virginia Commonwealth University, Richmond, VA, USA.
Mark MalkinDepartment of Neurology, School of Medicine, Virginia Commonwealth University, 1201 East Marshall St, Richmond, VA, 23298-0037, USA.
Leroy ThackerMassey Cancer Center, Richmond, VA, USA.
Virginia Commonwealth University · USPrincess Margaret Cancer Centre · CA

Funding

Institutional Career Development CoreKL2TR002648 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI NANASINKAM, SERGE PATRICK, SANYAL, ARUN J · 2018 to 2022
$3.7M
CTSA K12 Program at Virginia Commonwealth UniversityK12TR004364 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI SERGE PATRICK NANASINKAM, Gretchen N Neigh · 2023 to 2026
$3.0M
American Cancer Society - Institutional Research Grant IRG-18-159-43NCATS NIH HHS K12 TR004364NCATS NIH HHS KL2 TR002648NCATS NIH HHS KL2TR002648
6 · The paper itself

Abstract

backgroundManaging Cancer and Living Meaningfully (CALM) is an evidence-based, brief, semi-structured psychotherapy designed to help patients with advanced cancer cope with the practical and profound challenges of their illness. However, no study to date has investigated its feasibility, acceptability, and preliminary effectiveness in adults with malignant glioma, despite the well-documented incidence of psychological distress in this vulnerable and underserved population.

methodsFourteen patients with glioma and elevated symptoms of depression and/or death anxiety enrolled in the trial: 83% glioblastoma, 75% female, M

resultsOf the 14 enrolled patients, 12 were evaluable. Nine completed the study (75% retention rate). Three patients withdrew due to substantial disease progression which affected their ability to participate. Participants reported high perceived benefit, and all recommended the program to others. Baseline to post-intervention assessments indicated reductions in death anxiety, generalized anxiety, and depression, and increases in spirituality. Quality of life and fear of cancer recurrence remained stable throughout the study period.

conclusionsCALM appears feasible for use with adults with malignant glioma. Enrollment and retention rates were high and comparable to psychotherapy trials for patients with advanced cancer. High perceived benefit and reductions in symptoms of death anxiety, generalized anxiety, and depression were reported by participants. These findings are extremely encouraging and support further study of CALM in neuro-oncology. TRIAL REGISTRATION NUMBER: NCT04646213 registered on 11/27/2020.

Indexed as

GliomaPsychotherapy, BriefAdultAnxietyDepressionFeasibility StudiesFemaleHumansMaleMiddle AgedNeoplasm Recurrence, LocalQuality of LifeAcceptabilityCALMDeath anxietyDepressionFeasibilityGliomaPsychotherapy

Identifiers

PMID35437687
PMCPMC9909556
OpenAlexW4224239303

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.