ArticleNature immunology2022
PD-L1-PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection.
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In one paragraph
Article in Nature immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 91 citations in OpenAlex.
- Review
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- Immunological maladaptation preceding spontaneous preterm birth in human pregnancies.Nature communications · 2026Article
- Spatial transcriptomics identifies immune-stromal niches associated with cancer in adult dermatomyositis.Nature communications · 2026Article
- The dual balance of the cytokine network: key messengers of immune activation and triggers of cytokine storm.Biomarker research · 2026Review
- Increased Nur77 is disconnected from TCR affinity in insulin-specific Tregs.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Chemokine-defined macrophage niches establish spatial organization of tumor immunity.Nature immunology · 2026Article
- PD-1, BTLA and TIGIT as therapeutic targets for rheumatic disease.Nature reviews. Rheumatology · 2026Review
- Hair follicle immune privilege in autoimmune and immune-mediated alopecias: paths toward reestablishing immune tolerance.Frontiers in medicine · 2026Review
- T cell exhaustion in parasitic infections.Frontiers in immunology · 2026Review
- Regulatory T Cells and Nanomaterials: Dual Perspectives in Therapeutics and Immunomodulation.Small science · 2026Review
- PD-L1-centric whole blood-based immune signature profiles of tuberculosis patients during therapy.Frontiers in immunology · 2026Article
- IL-27 promotes Treg cell expression of CD122 and fitness at homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Creation and Implementation of the Modern Treatment in Eimeria and Esophagostomiasis Invasion: Case Report in the Farms "Ulan", "Erlan", and "Balke".Archives of Razi Institute · 2025Article
- sRAGE inhibits myocardial ischemia/reperfusion injuries via regulating Treg cells.Cell & bioscience · 2025Article
- Intestinal epithelial Ceacam1 deficiency prevents steroid-refractory acute gut graft-versus-host disease.JCI insight · 2025Article
- Exploring the Functional Role of Programmed Death-Ligand 1 (PD-L1) in the Castration-Resistant Prostate Cancer Using Transcriptomic Sequencing Analysis.Cancer medicine · 2025Article
- Resistance to anti-PD-1 therapy is driven by CD30Nature immunology · 2025Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 4 institutions in 1 country.
Joseph A PerryDepartment of Pathobiology, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-2341-8461
Lindsey ShallbergDepartment of Pathobiology, University of Pennsylvania, Philadelphia, PA, USA.
Joseph T ClarkDepartment of Pathobiology, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-7764-6000
Jodi A GullicksrudDepartment of Pathobiology, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-1666-9983
Jonathan H DeLongDepartment of Pathobiology, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-2032-8228
Bonnie B DouglasDepartment of Pathobiology, University of Pennsylvania, Philadelphia, PA, USA.
Andrew P HartDepartment of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Zachary LanzarDepartment of Pathobiology, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-7229-0973
Keenan O'DeaDepartment of Pathobiology, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-9278-0697
Christoph KonradtDepartment of Pathobiology, University of Pennsylvania, Philadelphia, PA, USA.
Jeongho ParkDepartment of Pathobiology, University of Pennsylvania, Philadelphia, PA, USA.
Juhi R KuchrooDepartment of Immunology, Harvard Medical School, Boston, MA, USA.
Daniel GrubaughDepartment of Pathobiology, University of Pennsylvania, Philadelphia, PA, USA.
Arielle Glatman ZaretskyDepartment of Pathobiology, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-2247-3170
Igor E BrodskyDepartment of Pathobiology, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-7970-872X
Rene de Waal MalefytMerck & Co., Kenilworth, NJ, USA.ORCID http://orcid.org/0000-0002-2663-383X
David A ChristianDepartment of Pathobiology, University of Pennsylvania, Philadelphia, PA, USA.
Arlene H SharpeDepartment of Immunology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9736-2109
Christopher A HunterDepartment of Pathobiology, University of Pennsylvania, Philadelphia, PA, USA. chunter@vet.upenn.edu.ORCID http://orcid.org/0000-0003-3092-1428
University of Pennsylvania · USHarvard University · USMerck & Co., Inc., Rahway, NJ, USA (United States) · USPurdue University West Lafayette · US
Funding
Role of Negative Costimulation in Regulation of AutoimmunityP01AI039671 · NIAID · YALE UNIVERSITY · PI David A. Hafler · 1996 to 2026
$51.7MTransgenic/KnockoutP01AI056299 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI BLAZAR, BRUCE R · 2003 to 2023
$42.5MSynergies among inhibitory receptors in tolerance, cancer & antiviral immunityP01AI108545 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Dario AA Vignali · 2015 to 2026
$30.8MIMMUNOBIOLOGY OF NORMAL AND NEOPLASTIC LYMPHOCYTEST32CA009140 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Malay Haldar, WARREN S PEAR · 1985 to 2026
$16.1MIMMUNOPATHOGENESIS OF TOXOPLASMIC ENCEPHALITISR01AI041158 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HUNTER, CHRISTOPHER A · 1996 to 2019
$4.8MImpact of early T-bet on CD8 T cell effector responsesR01AI125563 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HUNTER, CHRISTOPHER A · 2016 to 2020
$2.0MOrigins of serum IgA antibodiesR01AI113543 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ALLMAN, DAVID M · 2014 to 2017
$1.6MNovel role of DC1 in vaccine induced CD8 T cell responsesR21AI139895 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HUNTER, CHRISTOPHER A · 2019 to 2020
$443kNCI NIH HHS T32 CA009140NIAID NIH HHS P01 AI039671NIAID NIH HHS P01 AI056299NIAID NIH HHS R01 AI041158NIAID NIH HHS R01 AI113543NIAID NIH HHS R01 AI125563NIAID NIH HHS R21 AI139895
Abstract
Phenotypic and transcriptional profiling of regulatory T (T
Indexed as
B7-H1 AntigenProgrammed Cell Death 1 ReceptorT-Lymphocytes, RegulatoryToxoplasmosis, AnimalAnimalsHomeostasisInterleukin-10MiceToxoplasmaB7-H1 AntigenCD274 protein, humanInterleukin-10Pdcd1 protein, mouseProgrammed Cell Death 1 Receptor
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What OpenQuestion holds
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.