Evidence map›Paper›PMID 35437278›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

Cone-Driven Retinal Responses Are Shaped by Rod But Not Cone HCN1.

Colten K Lankford, Yumiko Umino, Deepak Poria, Vladimir Kefalov, Eduardo Solessio, Sheila A Baker

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Retinal Dysfunction in a Mouse Model of HCN1 Genetic Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Colten K LankfordDepartment of Biochemistry and Molecular Biology, University of Iowa, Iowa City, Iowa 52242.
Yumiko UminoCenter for Vision Research, Department of Ophthalmology and Visual Sciences, State University of New York Upstate Medical University, Syracuse, New York 13210.
Deepak PoriaDepartment of Ophthalmology, Gavin Herbert Eye Institute, University of California, Irvine, California 92697.
Vladimir KefalovDepartment of Ophthalmology, Gavin Herbert Eye Institute, University of California, Irvine, California 92697.
Eduardo SolessioCenter for Vision Research, Department of Ophthalmology and Visual Sciences, State University of New York Upstate Medical University, Syracuse, New York 13210.
Sheila A BakerDepartment of Biochemistry and Molecular Biology, University of Iowa, Iowa City, Iowa 52242 sheila-baker@uiowa.edu.ORCID https://orcid.org/0000-0002-0259-0652
SUNY Upstate Medical University · USUniversity of California, Irvine · USUniversity of Iowa · US

Funding

Protein Targeting in Vertebrate PhotoreceptorsR01EY020542 · NEI · UNIVERSITY OF IOWA · PI BAKER, SHEILA A · 2010 to 2021
$3.7M
Contribution of rod photoresponse inactivation kinetics to visual temporal contrast sensitivity in mesopic light.R01EY026216 · NEI · UPSTATE MEDICAL UNIVERSITY · PI SOLESSIO, EDUARDO C · 2016 to 2025
$3.5M
Opsin signaling in mammalian rod photoreceptorsR01EY030912 · NEI · WASHINGTON UNIVERSITY · PI KEFALOV, VLADIMIR JIVKOV, PALCZEWSKI, KRZYSZTOF · 2020 to 2023
$1.6M
CALCIUM HOMEOSTASIS IN MAMMALIAN ROD AND CONE PHOTORECEPTORSR01EY027387 · NEI · WASHINGTON UNIVERSITY · PI CHEN, JEANNIE, KEFALOV, VLADIMIR JIVKOV · 2017 to 2020
$1.4M
NEI NIH HHS R01 EY020542NEI NIH HHS R01 EY026216NEI NIH HHS R01 EY027387NEI NIH HHS R01 EY030912
6 · The paper itself

Abstract

Signal integration of converging neural circuits is poorly understood. One example is in the retina where the integration of rod and cone signaling is responsible for the large dynamic range of vision. The relative contribution of rods versus cones is dictated by a complex function involving background light intensity and stimulus temporal frequency. One understudied mechanism involved in coordinating rod and cone signaling onto the shared retinal circuit is the hyperpolarization activated current (

Indexed as

Nucleotides, CyclicRetinal Rod Photoreceptor CellsAnimalsElectroretinographyHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsMiceMice, KnockoutPotassium ChannelsRetinaRetinal Cone Photoreceptor CellsHcn1 protein, mouseHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsNucleotides, CyclicPotassium ChannelsconeERGHCN1light adaptationphotovoltagerod

Identifiers

PMID35437278
PMCPMC9145265
OpenAlexW4226073926

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.