Evidence map›Paper›PMID 35437265›Full record

ArticleeNeuro

Characterization of Hypothalamic MCH Neuron Development in a 3D Differentiation System of Mouse Embryonic Stem Cells.

Yu Kodani, Miho Kawata, Hidetaka Suga, Yoko S Kaneko, Akira Nakashima, Toshiki Kameyama, Kanako Saito, Hiroshi Nagasaki

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Central Role of Hypothalamic Circuits for Acupuncture's Anti-Parkinsonian Effects.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yu KodaniDepartment of Physiology, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan.
Miho KawataDepartment of Physiology, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan.
Hidetaka SugaDepartment of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan.
Yoko S KanekoDepartment of Physiology, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan.
Akira NakashimaDepartment of Physiological Chemistry, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan.
Toshiki KameyamaDepartment of Physiology, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan.ORCID 0000-0002-7348-7572
Kanako SaitoDepartment of Physiology, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan.
Hiroshi NagasakiDepartment of Physiology, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan hnagasak@fujita-hu.ac.jp.
Fujita Health University · JPNagoya University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypothalamic melanin-concentrating hormone (MCH) neurons are important regulators of multiple physiological processes, such as sleep, feeding, and memory. Despite the increasing interest in their neuronal functions, the molecular mechanism underlying MCH neuron development remains poorly understood. We report that a three-dimensional culture of mouse embryonic stem cells (mESCs) can generate hypothalamic-like tissues containing MCH-positive neurons, which reproduce morphologic maturation, neuronal connectivity, and neuropeptide/neurotransmitter phenotype of native MCH neurons. Using this

Indexed as

Hypothalamic HormonesMouse Embryonic Stem CellsAnimalsHedgehog ProteinsHypothalamusMelaninsMiceNerve Tissue ProteinsNeuronsOrexinsPituitary HormonesHedgehog ProteinsHypothalamic Hormonesmelanin-concentrating hormoneMelaninsNerve Tissue ProteinsOrexinsPituitary Hormones3D cultureES cellshypothalamusMCHneuronal differentiation

Identifiers

PMID35437265
PMCPMC9047030
OpenAlexW4224228061

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.