Evidence map›Paper›PMID 35437260›Full record

ArticleNeurology2022

Brain Metabolism Related to Mild Cognitive Impairment and Phenoconversion in Patients With Isolated REM Sleep Behavior Disorder.

Eun Jin Yoon, Jee-Young Lee, Heejung Kim, Dallah Yoo, Jung Hwan Shin, Hyunwoo Nam, Beomseok Jeon, Yu Kyeong Kim

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. [Movement disorders : official journal of the Movement Disorder Society · 2026
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  10. Review
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  13. Cognitive Impact of β-Amyloid Load in the Rapid Eye Movement Sleep Behavior Disorder-Lewy Body Disease Continuum.Movement disorders : official journal of the Movement Disorder Society · 2024
    Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Mild cognitive impairment in dementia with Lewy bodies: an update and outlook.Journal of neural transmission (Vienna, Austria : 1996) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Eun Jin YoonFrom the Memory Network (E.J.Y.) and Institute of Radiation Medicine (H.K.), Medical Research Center, Seoul National University; Departments of Nuclear Medicine (E.J.Y., H.K., Y.K.K.) and Neurology (J.-Y.L., D.Y., J.H.S., H.N.), Seoul National University-Seoul Metropolitan Government Boramae Medical Center, and Department of Neurology (B.J.), Seoul National University College of Medicine; and Department of Neurology (D.Y.), Kyung Hee University Hospital, Seoul, Korea.ORCID 0000-0003-4547-0420
Jee-Young LeeFrom the Memory Network (E.J.Y.) and Institute of Radiation Medicine (H.K.), Medical Research Center, Seoul National University; Departments of Nuclear Medicine (E.J.Y., H.K., Y.K.K.) and Neurology (J.-Y.L., D.Y., J.H.S., H.N.), Seoul National University-Seoul Metropolitan Government Boramae Medical Center, and Department of Neurology (B.J.), Seoul National University College of Medicine; and Department of Neurology (D.Y.), Kyung Hee University Hospital, Seoul, Korea.ORCID 0000-0002-9120-2075
Heejung KimFrom the Memory Network (E.J.Y.) and Institute of Radiation Medicine (H.K.), Medical Research Center, Seoul National University; Departments of Nuclear Medicine (E.J.Y., H.K., Y.K.K.) and Neurology (J.-Y.L., D.Y., J.H.S., H.N.), Seoul National University-Seoul Metropolitan Government Boramae Medical Center, and Department of Neurology (B.J.), Seoul National University College of Medicine; and Department of Neurology (D.Y.), Kyung Hee University Hospital, Seoul, Korea. yk3181@snu.ac.kr.ORCID 0000-0001-6215-5639
Dallah YooFrom the Memory Network (E.J.Y.) and Institute of Radiation Medicine (H.K.), Medical Research Center, Seoul National University; Departments of Nuclear Medicine (E.J.Y., H.K., Y.K.K.) and Neurology (J.-Y.L., D.Y., J.H.S., H.N.), Seoul National University-Seoul Metropolitan Government Boramae Medical Center, and Department of Neurology (B.J.), Seoul National University College of Medicine; and Department of Neurology (D.Y.), Kyung Hee University Hospital, Seoul, Korea.ORCID 0000-0002-9736-6118
Jung Hwan ShinFrom the Memory Network (E.J.Y.) and Institute of Radiation Medicine (H.K.), Medical Research Center, Seoul National University; Departments of Nuclear Medicine (E.J.Y., H.K., Y.K.K.) and Neurology (J.-Y.L., D.Y., J.H.S., H.N.), Seoul National University-Seoul Metropolitan Government Boramae Medical Center, and Department of Neurology (B.J.), Seoul National University College of Medicine; and Department of Neurology (D.Y.), Kyung Hee University Hospital, Seoul, Korea.
Hyunwoo NamFrom the Memory Network (E.J.Y.) and Institute of Radiation Medicine (H.K.), Medical Research Center, Seoul National University; Departments of Nuclear Medicine (E.J.Y., H.K., Y.K.K.) and Neurology (J.-Y.L., D.Y., J.H.S., H.N.), Seoul National University-Seoul Metropolitan Government Boramae Medical Center, and Department of Neurology (B.J.), Seoul National University College of Medicine; and Department of Neurology (D.Y.), Kyung Hee University Hospital, Seoul, Korea.
Beomseok JeonFrom the Memory Network (E.J.Y.) and Institute of Radiation Medicine (H.K.), Medical Research Center, Seoul National University; Departments of Nuclear Medicine (E.J.Y., H.K., Y.K.K.) and Neurology (J.-Y.L., D.Y., J.H.S., H.N.), Seoul National University-Seoul Metropolitan Government Boramae Medical Center, and Department of Neurology (B.J.), Seoul National University College of Medicine; and Department of Neurology (D.Y.), Kyung Hee University Hospital, Seoul, Korea.
Yu Kyeong KimFrom the Memory Network (E.J.Y.) and Institute of Radiation Medicine (H.K.), Medical Research Center, Seoul National University; Departments of Nuclear Medicine (E.J.Y., H.K., Y.K.K.) and Neurology (J.-Y.L., D.Y., J.H.S., H.N.), Seoul National University-Seoul Metropolitan Government Boramae Medical Center, and Department of Neurology (B.J.), Seoul National University College of Medicine; and Department of Neurology (D.Y.), Kyung Hee University Hospital, Seoul, Korea. yk3181@snu.ac.kr.
Seoul Metropolitan Government · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesMild cognitive impairment (MCI) in isolated REM sleep behavior disorder (iRBD) is a risk factor for subsequent neurodegeneration. We aimed to identify brain metabolism and functional connectivity changes related to MCI in patients with iRBD and the neuroimaging markers' predictive value for phenoconversion.

methodsThis is a prospective cohort study of patients with iRBD with a mean follow-up of 4.2 ± 2.6 years. At baseline, patients with iRBD and age- and sex-matched healthy controls (HCs) underwent

resultsForty patients with iRBD, including 21 with MCI (iRBD-MCI) and 19 with normal cognition (iRBD-NC), and 24 HCs were included in the study. The iRBD-MCI group revealed relative hypometabolism in the inferior parietal lobule, lateral and medial occipital, and middle and inferior temporal cortex bilaterally compared with HC and the iRBD-NC group. In seed-based connectivity analyses, the iRBD-MCI group exhibited decreased functional connectivity of the left angular gyrus with the occipital cortex. Of 40 patients with iRBD, 12 patients converted to Parkinson disease (PD) or dementia with Lewy bodies (DLB). Hypometabolism of the occipital pole (hazard ratio [95% CI] 6.652 [1.387-31.987]), medial occipital (4.450 [1.143-17.327]), and precuneus (3.635 [1.009-13.093]) was associated with higher phenoconversion rate to PD/DLB. DISCUSSION: MCI in iRBD is related to functional and metabolic changes in broad brain areas, particularly the occipital and parietal areas. Moreover, hypometabolism in these brain regions was a predictor of phenoconversion to PD or DLB. Evaluation of cognitive function and neuroimaging characteristics could be useful for risk stratification in patients with iRBD.

Indexed as

Cognitive DysfunctionParkinson DiseaseREM Sleep Behavior DisorderBrainFluorodeoxyglucose F18HumansProspective StudiesFluorodeoxyglucose F18

Identifiers

PMID35437260
PMCPMC9231839
OpenAlexW4224234720

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.