Evidence map›Paper›PMID 35437246›Full record

ArticleBMJ open2022

Balance on the Brain: a randomised controlled trial evaluating the effect of a multimodal exercise programme on physical performance, falls, quality of life and cognition for people with mild cognitive impairment-study protocol.

Elissa Burton, Keith Hill, Kathryn A Ellis, Anne-Marie Hill, Meggen Lowry, Rachael Moorin, Joanne A McVeigh, Angela Jacques, Kirk I Erickson, Joel Tate and 7 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 12 institutions in 4 countries.

Elissa BurtonCurtin School of Allied Health, Curtin University-Perth City Campus, Perth, Western Australia, Australia E.Burton@curtin.edu.au.ORCID 0000-0001-6470-8305
Keith HillRehabilitation, Ageing and Independent Living (RAIL) Research Centre, School of Primary and Allied Health Care, Monash University, Clayton, Victoria, Australia.
Kathryn A EllisThe Academic Unit for Psychiatry of Old Age, Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia.
Anne-Marie HillSchool of Allied Health, Western Australian Centre for Health and Ageing, The University of Western Australia, Perth, Western Australia, Australia.ORCID 0000-0003-1411-6752
Meggen LowryNext Step Health, Brisbane, Queensland, Australia.
Rachael MoorinCurtin School of Population Health, Curtin University, Perth, Western Australia, Australia.ORCID 0000-0001-8742-7151
Joanne A McVeighCurtin School of Allied Health, Curtin University, Perth, Western Australia, Australia.
Angela JacquesCurtin School of Allied Health, Curtin University, Perth, Western Australia, Australia.
Kirk I EricksonCenter for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Joel TateDepartment of Rehabilitation and Aged Care, Armadale Health Service, Armadale, Western Australia, Australia.
Sarah BernardCurtin School of Allied Health, Curtin University, Perth, Western Australia, Australia.
Carolyn F OrrCognitive Clinic, Royal Perth Hospital, Perth, Western Australia, Australia.
Luke BongiasciaPhysiotherapy Department, Adult Community and Allied Health Directorate, Rockingham Peel Group, Rockingham, Western Australia, Australia.
Roger ClarnetteMedical School, University of Western Australia, Perth, Western Australia, Australia.
Melanie L ClarkNeurosciences Unit, North Metropolitan Health Service Mental Health, Public Health and Dental Services, Perth, Western Australia, Australia.
Shannon WilliamsNeurogenetic Clinic and Physiotherapy Department, Royal Perth Hospital, Perth, Western Australia, Australia.
Nicola LautenschlagerAcademic Unit of Psychiatry of Old Age, University of Melbourne, Melbourne, Victoria, Australia.
Curtin University · AUThe University of Western Australia · AURoyal Perth Hospital · AUArmadale Health ServiceMonash University · AUNorth Metropolitan Health Service · AUQueensland Health · AURockingham Peel GroupThe Royal Melbourne Hospital · AUThe University of Melbourne · AUUniversity of Pittsburgh · USUniversity of the Witwatersrand · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionExercise and physical activity have been shown to improve cognition for people living with mild cognitive impairment (MCI). There is strong evidence for the benefits of aerobic exercise and medium evidence for participating in regular strength training for people with MCI. However, people living with MCI fall two times as often as those without cognitive impairment and the evidence is currently unknown as to whether balance training for people with MCI is beneficial, as has been demonstrated for older people without cognitive impairment. The aim of this study is to determine whether a balance-focused multimodal exercise intervention improves balance and reduces falls for people with MCI, compared with a control group receiving usual care. METHODS AND ANALYSIS: This single blind randomised controlled trial (Balance on the Brain) will be offered to 396 people with MCI living in the community. The multimodal exercise intervention consists of two balance programmes and a walking programme to be delivered by physiotherapists over a 6-month intervention period. All participants will be followed up over 12 months (for the intervention group, this involves 6-month intervention and 6-month maintenance). The primary outcomes are (1) balance performance and (2) rate of falls. Physical performance, levels of physical activity and sedentary behaviour, quality of life and cognition are secondary outcomes. A health economic analysis will be undertaken to evaluate the cost-effectiveness of the intervention compared with usual care. ETHICS AND DISSEMINATION: Ethics approval has been received from the South Metropolitan Health Service Human Research Ethics Committee (HREC), Curtin University HREC and the Western Australia Department of Health HREC; and approval has been received to obtain data for health costings from Services Australia. The results will be disseminated through peer-review publications, conference presentations and online platforms. TRIAL REGISTRATION NUMBER: ACTRN12620001037998; Australian New Zealand Clinical Trials Registry (ANZCTR).

Indexed as

Cognitive DysfunctionQuality of LifeAgedAustraliaBrainCognitionExerciseExercise TherapyHumansPhysical Functional PerformanceRandomized Controlled Trials as TopicSingle-Blind Methodpreventive medicinepublic healthrehabilitation medicine

Identifiers

PMID35437246
PMCPMC9016395
OpenAlexW4224039912

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.